Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism

被引：7
作者：
Chen, Lu [1 ]
Zhu, Lin [1 ]
Lu, Di [2 ]
Wu, Zhe [3 ]
Han, Yanbing [1 ]
Xu, Puying [1 ]
Chang, Lvhua [1 ]
Wu, Qian [1 ]
机构：
[1] Kunming Med Univ, Affiliated Hosp 1, Dept Neurol, Kunming, Yunnan, Peoples R China
[2] Kunming Med Univ, Biomed Engn Res Ctr, Kunming, Yunnan, Peoples R China
[3] First Peoples Hosp Yunnan Prov, Dept Psychol, Kunming, Yunnan, Peoples R China
来源：
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2020年 / 13卷
基金：
中国国家自然科学基金;
关键词：
interleukin; 4; epilepsy; microglia; astrocytes; cognition; SINGLE-NUCLEOTIDE POLYMORPHISMS; NECROSIS-FACTOR-ALPHA; RECEPTOR-ALPHA; MICROGLIAL ACTIVATION; PILOCARPINE MODEL; IL-4; RECEPTORS; ASTROCYTES; SEIZURES; MOUSE; STAT3;
D O I：
10.3389/fnmol.2020.554547
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Epilepsy is a chronic brain dysfunction induced by an abnormal neuronal discharge that is caused by complicated psychopathologies. Recently, accumulating studies have revealed a close relationship between inflammation and epilepsy. Specifically, microglia and astrocytes are important inflammatory cells in the central nervous system (CNS) that have been proven to be related to the pathogenesis and development of epilepsy. Additionally, interleukin 4 (IL-4) is an anti-inflammatory factor that can regulate microglia and astrocytes in many aspects. This review article focuses on the regulatory role of IL-4 in the pathological changes of glial cells related to epilepsy. We additionally propose that IL-4 may play a protective role in epileptogenesis and suggest that IL-4 may be a novel therapeutic target for the treatment of epilepsy.
引用
收藏
页数：11
相关论文
共 90 条
  • [1] Comorbidity and Childhood Epilepsy: A Nationwide Registry Study
    Aaberg, Kari Modalsli
    Bakken, Inger Johanne
    Lossius, Morten I.
    Soraas, Camilla Lund
    Haberg, Siri Eldevik
    Stoltenberg, Camilla
    Suren, Pal
    Chin, Richard
    [J]. PEDIATRICS, 2016, 138 (03)
  • [2] Intracerebral delivery of the M2 polarizing cytokine interleukin 13 using mesenchymal stem cell implants in a model of temporal lobe epilepsy in mice
    Ali, Idrish
    Aertgeerts, Stephanie
    Le Blon, Debbie
    Bertoglio, Daniele
    Hoornaert, Chloe
    Ponsaerts, Peter
    Dedeurwaerdere, Stefanie
    [J]. EPILEPSIA, 2017, 58 (06) : 1063 - 1072
  • [3] The association of the cytoplasmic domains of interleukin 4 receptor alpha and interleukin 13 receptor alpha 2 regulates interleukin 4 signaling
    Andrews, Allison-Lynn
    Nordgren, Ida Karin
    Campbell-Harding, Gemma
    Holloway, John W.
    Holgate, Stephen T.
    Davies, Donna E.
    Tavassoli, Ali
    [J]. MOLECULAR BIOSYSTEMS, 2013, 9 (12) : 3009 - 3014
  • [4] Targeting cell signaling in allergic asthma
    Athari, Seyyed Shamsadin
    [J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2019, 4 (1)
  • [5] IL-4/IL-13 Heteroreceptor Influences Th17 Cell Conversion and Sensitivity to Regulatory T Cell Suppression To Restrain Experimental Allergic Encephalomyelitis
    Barik, Subhasis
    Ellis, Jason S.
    Cascio, Jason A.
    Miller, Mindy M.
    Ukah, Tobechukwu K.
    Cattin-Roy, Alexis N.
    Zaghouani, Habib
    [J]. JOURNAL OF IMMUNOLOGY, 2017, 199 (07) : 2236 - 2248
  • [6] Astrocytes are a specific immunological target in Rasmussen's encephalitis
    Bauer, Jan
    Eiger, Christian E.
    Hans, Volkmar H.
    Schramm, Johannes
    Urbach, Horst
    Lassmann, Hans
    Bien, Christian G.
    [J]. ANNALS OF NEUROLOGY, 2007, 62 (01) : 67 - 80
  • [7] The Epidemiology of Epilepsy
    Beghi, Ettore
    [J]. NEUROEPIDEMIOLOGY, 2020, 54 (02) : 185 - 191
  • [8] Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models
    Benson, Melissa J.
    Manzanero, Silvia
    Borges, Karin
    [J]. EPILEPSIA, 2015, 56 (06) : 895 - 905
  • [9] Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain
    Bhattarai, Prabesh
    Cosacak, Mehmet Ilyas
    Mashkaryan, Violeta
    Demir, Sevgican
    Popova, Stanislava Dimitrova
    Govindarajan, Nambirajan
    Brandt, Kerstin
    Zhang, Yixin
    Chang, Weipang
    Ampatzis, Konstantinos
    Kizil, Caghan
    [J]. PLOS BIOLOGY, 2020, 18 (01)
  • [10] IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain
    Bhattarai, Prabesh
    Thomas, Alvin Kuriakose
    Cosacak, Mehmet Ilyas
    Papadimitriou, Christos
    Mashkaryan, Violeta
    Froc, Cynthia
    Reinhardt, Susanne
    Kurth, Thomas
    Dahl, Andreas
    Zhang, Yixin
    Kizil, Caghan
    [J]. CELL REPORTS, 2016, 17 (04): : 941 - 948
123456789