The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts

被引：20

作者：

Bravo-San Pedro, Jose M. ^{[1
]}

Gomez-Sanchez, Ruben ^{[1
]}

Niso-Santano, Mireia ^{[1
]}

Pizarro-Estrella, Elisa ^{[1
]}

Aiastui-Pujana, Ana ^{[2
]}

Gorostidi, Ana ^{[2
]}

Climent, Vicente ^{[3
]}

Lopez de Maturana, Rakel ^{[4
]}

Sanchez-Pernaute, Rosario ^{[4
]}

Lopez de Munain, Adolfo ^{[5
]}

Fuentes, Jose M. ^{[1
]}

Gonzalez-Polo, Rosa A. ^{[1
]}

机构：

[1] Univ Extremadura, Dept Bioquim & Biol Mol & Genet, E Enfermeria & TO, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Caceres, Spain

[2] Ilundain Fdn, Hosp Donosti, Lab Neurogenet, San Sebastian, Spain

[3] Univ Extremadura, Fac Med, Dept Anat & Embriol Humana, Badajoz, Spain

[4] Fdn Inbiomed, Lab Celulas Madre & Neurorreparac, San Sebastian, Spain

[5] Hosp Donosti, Serv Neurol, Inst Biodonostia, Ctr Invest Biomed Red Enfermedades Neurodegenerat, San Sebastian, Spain

来源：

AUTOPHAGY | 2012年 / 8卷 / 10期

关键词：

autophagy; LRRK2; G2019S; MAPK1/3; Parkinson disease;

D O I：

10.4161/auto.21270

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The link between the deregulation of autophagy and cell death processes can be essential in the development of several neurodegenerative diseases, such as Parkinson disease (PD). However, the molecular mechanism of deregulation of this degradative process in PD patients is unknown. The leucine-rich repeat kinase 2 (LRRK2) gene is related to PD and its implication in autophagy regulation has been described. Our recent work shows that the presence of the G2019S LRRK2 mutation, one of the most prevalent in LRRK2, is accompanied by a deregulation of autophagy basal levels dependent on the MAPK1/3 (ERK2/1) pathway. © 2012 Landes Bioscience.

引用

页码：1537 / 1539

页数：3

共 24 条

[21] Wild-type and mutant (G2019S) leucine-rich repeat kinase 2 (LRRK2) associate with subunits of the translocase of outer mitochondrial membrane (TOM) complex
Neethling, Annika
Engelbrecht, Lize
Loos, Ben
Kinnear, Craig
Theart, Rensu
Abrahams, Shameemah
Niesler, Thomas
Mellick, George D.
Williams, Monique
Bardien, Soraya
EXPERIMENTAL CELL RESEARCH, 2019, 375 (02) : 72 - 79
[22] LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity
Karuppagounder, Senthilkumar S.
Xiong, Yulan
Lee, Yunjong
Lawless, Maeve C.
Kim, Donghyun
Nordquist, Emily
Martin, Ian
Ge, Preston
Brahmachari, Saurav
Jhaldiyal, Aanishaa
Kumar, Manoj
Andrabia, Shaida A.
Dawson, Ted M.
Dawson, Valina L.
JOURNAL OF CHEMICAL NEUROANATOMY, 2016, 76 : 90 - 97
[23] Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects
Borgs, Laurence
Peyre, Elise
Alix, Philippe
Hanon, Kevin
Grobarczyk, Benjamin
Godin, Juliette D.
Purnelle, Audrey
Krusy, Nathalie
Maquet, Pierre
Lefebvre, Philippe
Seutin, Vincent
Malgrange, Brigitte
Laurent Nguyen
SCIENTIFIC REPORTS, 2016, 6
[24] The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A
Rivero-Rios, Pilar
Romo-Lozano, Maria
Madero-Perez, Jesus
Thomas, Andrew P.
Biosa, Alice
Greggio, Elisa
Hilfiker, Sabine
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 294 (13) : 4738 - 4758

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