DsbA is required for stable expression of outer membrane protein YscC and for efficient Yop secretion in Yersinia pestis

被引：54

作者：

Jackson, MW ^{[1
]}

Plano, GV ^{[1
]}

机构：

[1] Univ Miami, Sch Med, Dept Microbiol & Immunol, Miami, FL 33176 USA

来源：

JOURNAL OF BACTERIOLOGY | 1999年 / 181卷 / 16期

关键词：

D O I：

10.1128/JB.181.16.5126-5130.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The role of the periplasmic disulfide oxidoreductase DsbA in Yop secretion was investigated in Yersinia pestis. A Y. pestis dsbA mutant secreted reduced amounts of the V antigen and Yops and expressed reduced amounts of the full-sized YscC protein. Site-directed mutagenesis of the four cysteine residues present in the YscC protein resulted in defects similar to those found in the dsbA mutant. These results suggest that YscC contains at least one disulfide bond that is essential for the function of this protein in Yop secretion.

引用

页码：5126 / 5130

页数：5

共 31 条

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