Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease

被引:579
作者
Petzinger, Giselle M. [1 ,2 ]
Fisher, Beth E. [2 ]
McEwen, Sarah [3 ]
Beeler, Jeff A. [4 ]
Walsh, John P. [5 ]
Jakowec, Michael W. [1 ,2 ]
机构
[1] Univ So Calif, Dept Neurol, Los Angeles, CA 90089 USA
[2] Univ So Calif, Div Biokinesiol & Phys Therapy, Los Angeles, CA 90089 USA
[3] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA
[4] Univ Chicago, Dept Neurobiol, Chicago, IL USA
[5] Univ So Calif, Andrus Gerontol, Los Angeles, CA 90089 USA
基金
美国国家卫生研究院;
关键词
1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-LESIONED MOUSE MODEL; RANDOMIZED CONTROLLED-TRIAL; BASAL GANGLIA; PHYSICAL-ACTIVITY; SYNAPTIC PLASTICITY; BEHAVIORAL RECOVERY; TREADMILL EXERCISE; NEURAL PLASTICITY; VIRTUAL-REALITY; ARGENTINE TANGO;
D O I
10.1016/S1474-4422(13)70123-6
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Exercise interventions in individuals with Parkinson's disease incorporate goal-based motor skill training to engage cognitive circuitry important in motor learning. With this exercise approach, physical therapy helps with learning through instruction and feedback (reinforcement) and encouragement to perform beyond self-perceived capability. Individuals with Parkinson's disease become more cognitively engaged with the practice and learning of movements and skills that were previously automatic and unconscious. Aerobic exercise, regarded as important for improvement of blood flow and facilitation of neuroplasticity in elderly people, might also have a role in improvement of behavioural function in individuals with Parkinson's disease. Exercises that incorporate goal-based training and aerobic activity have the potential to improve both cognitive and automatic components of motor control in individuals with mild to moderate disease through experience-dependent neuroplasticity. Basic research in animal models of Parkinson's disease is beginning to show exercise-induced neuroplastic effects at the level of synaptic connections and circuits.
引用
收藏
页码:716 / 726
页数:11
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