Brain-responsive neurostimulation for epilepsy (RNS® System)

被引：141

作者：

Skarpaas, Tara L. ^{[1
]}

Jarosiewicz, Beata ^{[1
]}

Morrell, Martha J. ^{[1
,2
]}

机构：

[1] NeuroPace Inc, Mountain View, CA USA

[2] Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

来源：

EPILEPSY RESEARCH | 2019年 / 153卷

关键词：

Responsive; Neurostimulation; Closed-loop; Epilepsy; Medically intractable epilepsy; Focal onset; Brain-responsive neurostimulation; STIMULATION; ADULTS;

D O I：

10.1016/j.eplepsyres.2019.02.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Controlled clinical trials in adults with medically intractable focal seizures treated with the RNS (R) System demonstrate that closed-loop responsive neurostimulation to the seizure focus reduces the frequency of disabling seizures, is well tolerated, and is acceptably safe. Seizure reductions begin with initiation of treatment and continue over time, reaching median reductions of 75% after 9 years of treatment. Treatment with responsive cortical stimulation is also associated with improvement in quality of life and cognitive function related to the functional area being treated. In addition, the RNS System's chronic ambulatory electrocorticographic monitoring provides unprecedented insight into each patient's disease management, and into the study of epilepsy itself, in ways that may enhance the treatment of epilepsy in the future.

引用

页码：68 / 70

页数：3

共 19 条

[1]

[Anonymous], 2018, NEUROPACE RNS SYSTEM

[2] Multi-day rhythms modulate seizure risk in epilepsy [J].

Baud, Maxime O. ;

Kleen, Jonathan K. ;

Mirro, Emily A. ;

Andrechak, Jason C. ;

King-Stephens, David ;

Chang, Edward F. ;

Rao, Vikram R. .

NATURE COMMUNICATIONS, 2018, 9

[3] Long-term treatment with responsive brain stimulation in adults with refractory partial seizures [J].

Bergey, Gregory K. ;

Morrell, Martha J. ;

Mizrahi, Eli M. ;

Goldman, Alica ;

King-Stephens, David ;

Nair, Dileep ;

Srinivasan, Shraddha ;

Jobst, Barbara ;

Gross, Robert E. ;

Shields, Donald C. ;

Barkley, Gregory ;

Salanova, Vicenta ;

Olejniczak, Piotr ;

Cole, Andrew ;

Cash, Sydney S. ;

Noe, Katherine ;

Wharen, Robert ;

Worrell, Gregory ;

Murro, Anthony M. ;

Edwards, Jonathan ;

Duchowny, Michael ;

Spencer, David ;

Smith, Michael ;

Geller, Eric ;

Gwinn, Ryder ;

Skidmore, Christopher ;

Eisenschenk, Stephan ;

Berg, Michel ;

Heck, Christianne ;

Van Ness, Paul ;

Fountain, Nathan ;

Rutecki, Paul ;

Massey, Andrew ;

O'Donovan, Cormac ;

Labar, Douglas ;

Duckrow, Robert B. ;

Hirsch, Lawrence J. ;

Courtney, Tracy ;

Sun, Felice T. ;

Seale, Cairn G. .

NEUROLOGY, 2015, 84 (08) :810-817

[4] Chronic unlimited recording electrocorticography-guided resective epilepsy surgery: technology-enabled enhanced fidelity in seizure focus localization with improved surgical efficacy Clinical article [J].

DiLorenzo, Daniel J. ;

Mangubat, Erwin Z. ;

Rossi, Marvin A. ;

Byrne, Richard W. .

JOURNAL OF NEUROSURGERY, 2014, 120 (06) :1402-1414

[5] Complementary effect of surgical resection and responsive brain stimulation in the treatment of bitemporal lobe epilepsy: A case report [J].

Enatsu, Rei ;

Alexopoulos, Andreas ;

Bingaman, William ;

Nair, Dileep .

EPILEPSY & BEHAVIOR, 2012, 24 (04) :513-516

[6] Brain-responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy [J].

Geller, Eric B. ;

Skarpaas, Tara L. ;

Gross, Robert E. ;

Goodman, Robert R. ;

Barkley, Gregory L. ;

Bazil, Carl W. ;

Berg, Michael J. ;

Bergey, Gregory K. ;

Cash, Sydney S. ;

Cole, Andrew J. ;

Duckrow, Robert B. ;

Edwards, Jonathan C. ;

Eisenschenk, Stephan ;

Fessler, James ;

Fountain, Nathan B. ;

Goldman, Alicia M. ;

Gwinn, Ryder P. ;

Heck, Christianne ;

Herekar, Aamar ;

Hirsch, Lawrence J. ;

Jobst, Barbara C. ;

King-Stephens, David ;

Labar, Douglas R. ;

Leiphart, James W. ;

Marsh, W. Richard ;

Meador, Kimford J. ;

Mizrahi, Eli M. ;

Murro, Anthony M. ;

Nair, Dileep R. ;

Noe, Katherine H. ;

Park, Yong D. ;

Rutecki, Paul A. ;

Salanova, Vicenta ;

Sheth, Raj D. ;

Shields, Donald C. ;

Skidmore, Christopher ;

Smith, Michael C. ;

Spencer, David C. ;

Srinivasan, Shraddha ;

Tatum, William ;

Van Ness, Paul C. ;

Vossler, David G. ;

Wharen, Robert E. ;

Worrell, Gregory A. ;

Yoshor, Daniel ;

Zimmerman, Richard S. ;

Cicora, Kathy ;

Sun, Felice T. ;

Morrell, Martha J. .

EPILEPSIA, 2017, 58 (06) :994-1004

[7] Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial [J].

Heck, Christianne N. ;

King-Stephens, David ;

Massey, Andrew D. ;

Nair, Dileep R. ;

Jobst, Barbara C. ;

Barkley, Gregory L. ;

Salanova, Vicenta ;

Cole, Andrew J. ;

Smith, Michael C. ;

Gwinn, Ryder P. ;

Skidmore, Christopher ;

Van Ness, Paul C. ;

Bergey, Gregory K. ;

Park, Yong D. ;

Miller, Ian ;

Geller, Eric ;

Rutecki, Paul A. ;

Zimmerman, Richard ;

Spencer, David C. ;

Goldman, Alica ;

Edwards, Jonathan C. ;

Leiphart, James W. ;

Wharen, Robert E. ;

Fessler, James ;

Fountain, Nathan B. ;

Worrell, Gregory A. ;

Gross, Robert E. ;

Eisenschenk, Stephan ;

Duckrow, Robert B. ;

Hirsch, Lawrence J. ;

Bazil, Carl ;

O'Donovan, Cormac A. ;

Sun, Felice T. ;

Courtney, Tracy A. ;

Seale, Cairn G. ;

Morrell, Martha J. .

EPILEPSIA, 2014, 55 (03) :432-441

[8] Brain-responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas [J].

Jobst, Barbara C. ;

Kapur, Ritu ;

Barkley, Gregory L. ;

Bazil, Carl W. ;

Berg, Michel J. ;

Bergey, Gregory K. ;

Boggs, Jane G. ;

Cash, Sydney S. ;

Cole, Andrew J. ;

Duchowny, Michael S. ;

Duckrow, Robert B. ;

Edwards, Jonathan C. ;

Eisenschenk, Stephan ;

Fessler, A. James ;

Fountain, Nathan B. ;

Geller, Eric B. ;

Goldman, Alica M. ;

Goodman, Robert R. ;

Gross, Robert E. ;

Gwinn, Ryder P. ;

Heck, Christianne ;

Herekar, Aamr A. ;

Hirsch, Lawrence J. ;

King-Stephens, David ;

Labar, Douglas R. ;

Marsh, W. R. ;

Meador, Kimford J. ;

Miller, Ian ;

Mizrahi, Eli M. ;

Murro, Anthony M. ;

Nair, Dileep R. ;

Noe, Katherine H. ;

Olejniczak, Piotr W. ;

Park, Yong D. ;

Rutecki, Paul ;

Salanova, Vicenta ;

Sheth, Raj D. ;

Skidmore, Christopher ;

Smith, Michael C. ;

Spencer, David C. ;

Srinivasan, Shraddha ;

Tatum, William ;

Van Ness, Paul ;

Vossler, David G. ;

Wharen, Robert E., Jr. ;

Worrell, Gregory A. ;

Yoshor, Daniel ;

Zimmerman, Richard S. ;

Skarpaas, Tara L. ;

Morrell, Martha J. .

EPILEPSIA, 2017, 58 (06) :1005-1014

[9] Differential neuropsychological outcomes following targeted responsive neurostimulation for partial-onset epilepsy [J].

Loring, David W. ;

Kapur, Ritu ;

Meador, Kimford J. ;

Morrell, Martha J. .

EPILEPSIA, 2015, 56 (11) :1836-1844

[10] Quality of life and mood in patients with medically intractable epilepsy treated with targeted responsive neurostimulation [J].

Meador, Kimford J. ;

Kapur, Ritu ;

Loring, David W. ;

Kanner, Andres M. ;

Morrell, Martha J. .

EPILEPSY & BEHAVIOR, 2015, 45 :242-247

← 1 2 →