Mesenchymal hamartomas of the liver may be associated with increased serum alpha foetoprotein concentrations and mimic hepatoblastomas

被引：34

作者：

Boman, F ^{[1
]}

Bossard, C

Fabre, M

Diab, N

Bonnevalle, M

Boccon-Gibod, L

机构：

[1] CHRU, Hop Calmette, F-59037 Lille, France

[2] CHRU, Fac Med, Dept Pathol, F-59037 Lille, France

[3] Hop Bicetre, Assistance Publ Hop Paris, Le Kremlin Bicetre, France

[4] Fac Med Paris XI, Dept Pathol, Le Kremlin Bicetre, France

[5] Fac Med Paris XI, Dept Surg, Le Kremlin Bicetre, France

[6] CHRU, Hop Meres Enfants Jeanne Flandre, Dept Surg, Lille, France

[7] Hop Paris, Hop Enfants Armand Trosseau Assistance Publ, Paris 12, France

[8] Fac Med Paris VI, Dept Pathol, Paris 12, France

来源：

EUROPEAN JOURNAL OF PEDIATRIC SURGERY | 2004年 / 14卷 / 01期

关键词：

alpha fetoprotein; childhood; hepatoblastoma; mesenchymal hamartoma;

D O I：

10.1055/s-2004-815784

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A mesenchymal hamartoma (MH) of the liver in a seven-month-old girl was associated with slightly elevated alpha fetoprotein (AFP) concentrations (320 mug/L, normal < 25 after six months of age). Hepatocytes were abundant at the periphery of the tumour at histopathological examination. These were slightly atypical and expressed AFP immunohistochemically. In two other girls, aged 14 months and two months respectively, with MH and increased serum AFP concentrations (320 mug/L and 7500 mug/L, respectively), hepatoblastomas were misdiagnosed preoperatively. MH of the liver with increased serum AFP concentrations may thus mimic hepatoblastoma radiologically if cysts are lacking, and foetal hepatoblastoma pathologically if a biopsy samples only the peripheral hepatocellular component of the MH.

引用

页码：63 / 66

页数：4

共 15 条

[1]

[Anonymous], 2001, TUMORS LIVER INTRAHE

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