Osteopontin expression in salivary gland tumours

被引：13

作者：

Darling, MR ^{[1
]}

Gauthier, M ^{[1
]}

Jackson-Boeters, L ^{[1
]}

Daley, TD ^{[1
]}

Chambers, AF ^{[1
]}

Tuck, AB ^{[1
]}

机构：

[1] Univ Western Ontario, Dept Pathol, London, ON N6A 5C1, Canada

来源：

ORAL ONCOLOGY | 2006年 / 42卷 / 04期

关键词：

osteopontin; salivary gland tumours; prognostic markers; immunohistochemistry;

D O I：

10.1016/j.oraloncology.2005.09.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Osteopontin (OPN) is expressed in numerous carcinomas and plays a role in tumour development, invasion and metastasis. This study examines by immunohistochemistry the expression of OPN in normal salivary gland tissue and three types of salivary gland tumour: pleomorphic adenoma (PA), adenoid cystic carcinoma (ACC) and polymorphous tow grade adenocarcinoma (PLGA). PAs and PLGAs demonstrated higher levels of OPN than normal salivary gland tissue, white ACC, although showing a trend towards increased OPN, was not significantly different. The results of this study indicate that OPN expression is present in normal salivary gland tissue, and is increased in certain salivary gland tumours, but further investigation is necessary to clarify its rote. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：363 / 369

页数：7

共 32 条

[1] ASSOCIATION OF P53 PROTEIN EXPRESSION WITH TUMOR-CELL PROLIFERATION RATE AND CLINICAL OUTCOME IN NODE-NEGATIVE BREAST-CANCER [J].

ALLRED, DC ;

CLARK, GM ;

ELLEDGE, R ;

FUQUA, SAW ;

BROWN, RW ;

CHAMNESS, GC ;

OSBORNE, CK ;

MCGUIRE, WL .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (03) :200-206

[2] Immunohistochemical detection of the expression of the cell adhesion molecules E-cadherin, desmoglein-2, beta4-integrin, ICAM-1 and HCAM (CD44s) in Warthin's tumour of the parotid gland [J].

Andreadis, D ;

Epivatianos, A ;

Poulopoulos, A ;

Nomikos, A ;

Christidis, K ;

Papazoglou, G ;

Antoniades, D ;

Barbatis, C .

ORAL ONCOLOGY, 2005, 41 (08) :799-805

[3]

Araujo V C, 2001, Ann Diagn Pathol, V5, P330, DOI 10.1053/adpa.2001.29339

[4] EXPRESSION AND DISTRIBUTION OF OSTEOPONTIN IN HUMAN TISSUES - WIDESPREAD ASSOCIATION WITH LUMINAL EPITHELIAL SURFACES [J].

BROWN, LF ;

BERSE, B ;

VANDEWATER, L ;

PAPADOPOULOSSERGIOU, A ;

PERRUZZI, CA ;

MANSEAU, EJ ;

DVORAK, HF ;

SENGER, DR .

MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (10) :1169-1180

[5] Osteopontin expression in lung cancer [J].

Chambers, AF ;

Wilson, SM ;

Kerkvliet, N ;

OMalley, FP ;

Harris, JF ;

Casson, AG .

LUNG CANCER, 1996, 15 (03) :311-323

[6] Osteopontin induces multiple changes in gene expression that reflect the six "hallmarks of cancer" in a model of breast cancer progression [J].

Cook, AC ;

Tuck, AB ;

McCarthy, S ;

Turner, JG ;

Irby, RB ;

Bloom, GC ;

Yeatman, TJ ;

Chambers, AF .

MOLECULAR CARCINOGENESIS, 2005, 43 (04) :225-236

[7] Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies [J].

Coppola, D ;

Szabo, M ;

Boulware, D ;

Muraca, P ;

Alsarraj, M ;

Chambers, AF ;

Yeatman, TJ .

CLINICAL CANCER RESEARCH, 2004, 10 (01) :184-190

[8]

DARDICK I, 1996, COLOR ATLAS TEXT SAL, P211

[9] OSTEOPONTIN - A PROTEIN WITH DIVERSE FUNCTIONS [J].

DENHARDT, DT ;

GUO, XJ .

FASEB JOURNAL, 1993, 7 (15) :1475-1482

[10]

ELLIS GL, 1996, ATLAS TUMOR PATHOL, P216

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