Intrathecal baclofen for treatment of spasticity of multiple sclerosis patients

被引：32

作者：

Ben Smail, D

Peskine, A

Roche, N

Mailhan, L

Thiébaut, JB

Bussel, B

机构：

[1] Hop R Poincare, Serv Med Phys & Readaptat, F-92380 Garches, France

[2] Hop L Bellan, Serv Med Phys & Readaptat, F-75014 Paris, France

[3] Fdn Adolphe De Rothschild, Serv Neurochirurg, F-75019 Paris, France

来源：

MULTIPLE SCLEROSIS | 2006年 / 12卷 / 01期

关键词：

intrathecal baclofen; multiple sclerosis; spasms; spasticity;

D O I：

10.1191/1352458506ms1232sr

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We conducted a retrospective study of the case files of 64 multiple sclerosis (MS) patients presenting severe spasticity, who had received intrathecal (IT) baclofen test injections between 1992 and 2004 in a rehabilitation unit. In almost all cases of our series, IT baclofen was proposed to patients who were no longer able to walk. IT baclofen is a safe and effective treatment to reduce spasticity in MS patients. Despite an advanced stage of the disease at the time of pump placement, the complication rate was low and the efficacy of this treatment was maintained over time.

引用

页码：101 / 103

页数：3

共 10 条

[1]

ASHWORTH B, 1964, PRACTITIONER, V192, P540

[2] Intrathecal baclofen administration for control of severe spinal spasticity: Functional improvement and long-term follow-up [J].

Azouvi, P ;

Mane, M ;

Thiebaut, JB ;

Denys, P ;

RemyNeris, O ;

Bussel, B .

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 1996, 77 (01) :35-39

[3] INTRATHECAL BACLOFEN FOR INTRACTABLE SPASTICITY OF SPINAL ORIGIN - RESULTS OF A LONG-TERM MULTICENTER STUDY [J].

COFFEY, RJ ;

CAHILL, D ;

STEERS, W ;

PARK, TS ;

ORDIA, J ;

MEYTHALER, J ;

HERMAN, R ;

SHETTER, AG ;

LEVY, R ;

GILL, B ;

SMITH, R ;

WILBERGER, J ;

LOESER, JD ;

CHABAL, C ;

FELER, C ;

ROBERTSON, JT ;

PENN, RD ;

CLARKE, A ;

BURCHIEL, KJ ;

LEIBROCK, LG .

JOURNAL OF NEUROSURGERY, 1993, 78 (02) :226-232

[4]

Jarrett L, 2001, INT J MS CARE, V3, P10

[5]

Lazorthes Y, 1998, NEUROCHIRURGIE, V44, P201

[6] INTRATHECAL BACLOFEN FOR LONG-TERM TREATMENT OF SPASTICITY - A MULTI-CENTRE STUDY [J].

OCHS, G ;

STRUPPLER, A ;

MEYERSON, BA ;

LINDEROTH, B ;

GYBELS, J ;

GARDNER, BP ;

TEDDY, P ;

JAMOUS, A ;

WEINMANN, P .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1989, 52 (08) :933-939

[7] Chronic intrathecal delivery of baclofen by a programmable pump for the treatment of severe spasticity [J].

Ordia, JI ;

Fischer, E ;

Adamski, E ;

Spatz, EL .

JOURNAL OF NEUROSURGERY, 1996, 85 (03) :452-457

[8]

PENN RD, 1985, LANCET, V2, P125

[9]

PENN RD, 1984, LANCET, V1, P1078

[10] Prevalence and treatment of spasticity reported by multiple sclerosis patients [J].

Rizzo, MA ;

Hadjimichael, OC ;

Preiningerova, J ;

Vollmer, TL .

MULTIPLE SCLEROSIS, 2004, 10 (05) :589-595

← 1 →