sTREM-1 in patients with chronic kidney disease on hemodialysis

被引：21

作者：

Essa, Enas S. ^{[1
]}

Elzorkany, Khaled M. A. ^{[2
]}

机构：

[1] Menoufia Univ, Fac Med, Dept Clin Pathol, Shibin Al Kawm, Egypt

[2] Menoufia Univ, Fac Med, Dept Gen Med, Shibin Al Kawm, Egypt

来源：

APMIS | 2015年 / 123卷 / 11期

关键词：

sTREM-1; chronic kidney disease; hemodialysis; MYELOID CELLS-1 TREM-1; C-REACTIVE PROTEIN; EXPRESSION PATTERNS; CUTTING EDGE; INFLAMMATION; DIAGNOSIS; LUNG; CONSEQUENCES; MACROPHAGES; PNEUMONIA;

D O I：

10.1111/apm.12459

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily. TREM-1 has been implicated as an amplifier of inflammation. Soluble TREM-1 (sTREM-1) was investigated in different clinical conditions, but not in hemodialysis (HD) patients. We aimed to investigate sTREM-1 as a marker of inflammation in HD patients. We investigated 40 CKD patients undergoing chronic HD treatment and 15 controls. Routine laboratory investigations in addition to CRP measured by immunoturbidimetry, TNF- , and sTREM-1 measured by ELISA were assayed in post-hemodialysispatients' blood samples and in controls' blood samples. CRP, TNF-, and sTREM-1 levels were significantly higher in HD patients than in controls (p<0.001 for all). sTREM-1 was positively correlated with CRP and TNF- (r=+0.50, p<0.001 and r=+0.53, p<0.001 respectively). It was negatively correlated with hemoglobin concentration (r=-0.69, p<0.001). Hemoglobin concentration was the significant predictor of sTREM-1 level (p<0.001). In conclusion, sTREM-1 level is significantly increased in HD patients as are other pro-inflammatory markers.

引用

页码：969 / 974

页数：6

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