SUMOylation in atherosclerosis

被引：11
作者：
Liu, Yi-Zhang [1 ,2 ,3 ]
Xiao, Xuan [1 ,2 ,3 ]
Hu, Chu-Ting [1 ,2 ,4 ]
Dai, Yuan [1 ,2 ,5 ]
Qu, Shun-Lin [1 ]
Huang, Liang [2 ]
Zhang, Chi [1 ]
机构：
[1] Univ South China, Hengyang Med Coll, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, Hengyang 421001, Hunan, Peoples R China
[2] Univ South China, Hengyang Med Coll, Res Lab Clin & Translat Med, Hengyang 421001, Hunan, Peoples R China
[3] Univ South China, Hengyang Med Coll, Dept Clin Med, Hengyang 421001, Hunan, Peoples R China
[4] Univ South China, Hengyang Med Coll, Dept Med Lab, Hengyang 421001, Hunan, Peoples R China
[5] Univ South China, Chuanshan Coll, Dept Anaesthesiol, Hengyang 421001, Hunan, Peoples R China
来源：
CLINICA CHIMICA ACTA | 2020年 / 508卷
基金：
中国国家自然科学基金;
关键词：
Atherosclerosis; SUMO; Endothelial cell; Dyslipidemia; Vascular smooth muscle cells; MUSCLE-CELL PROLIFERATION; TRANSCRIPTIONAL PROGRAMS; INFLAMMATION; ACTIVATION; EXPRESSION; SUMO; CONTRIBUTES; DYSFUNCTION; MECHANISMS; BIOLOGY;
D O I：
10.1016/j.cca.2020.05.033
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Atherosclerosis (AS) is the pathophysiologic basis of many cardiovascular diseases. A number of studies have shown that post-translational modification (PTM) contributes to the initiation and progression of AS. For example, recent studies found that SUMOylation, ie, small ubiquitin-like modifier (SUMO) conjugation to target substrate proteins, was involved in AS. This PTM appears related to endothelial cell dysfunction (ECD), dyslipidemia and vascular smooth muscle cell (VSMC) proliferation. This review focuses on the molecular effects of SUMOylation in the initiation and progression of AS, including ECD, dyslipidemia and VSMC proliferation to better understand this pathologic process.
引用
收藏
页码：228 / 233
页数：6
相关论文
共 78 条
  • [1] Coordination of Cellular Localization-Dependent Effects of Sumoylation in Regulating Cardiovascular and Neurological Diseases
    Abe, Jun-ichi
    Sandhu, Uday G.
    Hoang, Nguyet Minh
    Thangam, Manoj
    Quintana-Quezada, Raymundo A.
    Fujiwara, Keigi
    Le, Nhat Tu
    [J]. SUMO REGULATION OF CELLULAR PROCESSES, 2ND EDITION, 2017, 963 : 337 - 358
  • [2] Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging
    Alique, Matilde
    Sanchez-Lopez, Elsa
    Bodega, Guillermo
    Giannarelli, Chiara
    Carracedo, Julia
    Ramirez, Rafael
    [J]. CELLS, 2020, 9 (01)
  • [3] HIV Proteins and Endothelial Dysfunction: Implications in Cardiovascular Disease
    Anand, Appakkudal R.
    Rachel, Gladys
    Parthasarathy, Durgadevi
    [J]. FRONTIERS IN CARDIOVASCULAR MEDICINE, 2018, 5
  • [4] Growth factor-induced phosphorylation of sterol regulatory element-binding proteins inhibits sumoylation, thereby stimulating the expression of their target genes, low density lipoprotein uptake, and lipid synthesis
    Arito, Mitsumi
    Horiba, Taro
    Hachimura, Satoshi
    Inoue, Jun
    Sato, Ryuichiro
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (22) : 15224 - 15231
  • [5] SUMO-mediated regulation of NLRP3 modulates inflammasome activity
    Barry, Rachael
    John, Sidonie Wicky
    Liccardi, Gianmaria
    Tenev, Tencho
    Jaco, Isabel
    Chen, Chih-Hong
    Choi, Justin
    Kasperkiewicz, Paulina
    Fernandes-Alnemri, Teresa
    Alnemri, Emad
    Drag, Marcin
    Chen, Yuan
    Meier, Pascal
    [J]. NATURE COMMUNICATIONS, 2018, 9
  • [6] Triciribine increases LDLR expression and LDL uptake through stabilization of LDLR mRNA
    Bjune, Katrine
    Wierod, Lene
    Naderi, Soheil
    [J]. SCIENTIFIC REPORTS, 2018, 8
  • [7] The ROS/SUMO Axis Contributes to the Response of Acute Myeloid Leukemia Cells to Chemotherapeutic Drugs
    Bossis, Guillaume
    Sarry, Jean-Emmanuel
    Kifagi, Chamseddine
    Ristic, Marko
    Saland, Estelle
    Vergez, Francois
    Salem, Tamara
    Boutzen, Helena
    Baik, Hayeon
    Brockly, Frederique
    Pelegrin, Mireia
    Kaoma, Tony
    Vallar, Laurent
    Recher, Christian
    Manenti, Stephane
    Piechaczyk, Marc
    [J]. CELL REPORTS, 2014, 7 (06): : 1815 - 1823
  • [8] Inhibition of PDGF-B Induction and Cell Growth by Syndecan-1 Involves the Ubiquitin and SUMO-1 Ligase, Topors
    Braun, Kathleen R.
    DeWispelaere, Allison M.
    Bressler, Steven L.
    Fukai, Nozomi
    Kenagy, Richard D.
    Chen, Lihua
    Clowes, Alexander W.
    Kinsella, Michael G.
    [J]. PLOS ONE, 2012, 7 (08):
  • [9] Intimal smooth muscle cells of porcine and human coronary artery express S100A4, a marker of the rhomboid phenotype in vitro
    Brisset, Anne C.
    Hao, Hiroyuki
    Camenzind, Edoardo
    Bacchetta, Marc
    Geinoz, Antoine
    Sanchez, Jean-Charles
    Chaponnier, Christine
    Gabbiani, Giulio
    Bochaton-Piallat, Marie-Luce
    [J]. CIRCULATION RESEARCH, 2007, 100 (07) : 1055 - 1062
  • [10] Functional Regulation of PPARs through Post-Translational Modifications
    Brunmeir, Reinhard
    Xu, Feng
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (06):
12345678