Modulatory impact of selected ellagitannins on the viability of human breast cancer cells

被引：16

作者：

Berdowska, Izabela ^{[1
]}

Zielinski, Bogdan ^{[1
]}

Saczko, Jolanta ^{[1
]}

Sopel, Miroslaw ^{[2
]}

Gamian, Andrzej ^{[1
]}

Fecka, Izabela ^{[3
]}

机构：

[1] Wroclaw Med Univ, Dept Med Biochem, Chalubinskiego 10, Wroclaw, Poland

[2] Wroclaw Med Univ, Dept Nervous Syst Dis, K Bartla 5, Wroclaw, Poland

[3] Wroclaw Med Univ, Dept Pharmacognosy, Borowska 211, Wroclaw, Poland

来源：

JOURNAL OF FUNCTIONAL FOODS | 2018年 / 42卷

关键词：

Ellagitannins; MTT assay; Breast cancer cells; MCF-7/Adr; MCF-7/wt; HYDROLYZABLE TANNINS; MULTIDRUG-RESISTANCE; ANTITUMOR-ACTIVITY; SANGUIIN H-6; ELLAGIC ACID; POLYPHENOLS; METABOLITES; AGRIMONIIN; MECHANISMS; INDUCTION;

D O I：

10.1016/j.jff.2017.12.053

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The impact of agrimoniin, sanguiin H-6, rugosins D and A, tellimagrandin I, and pedunculagin on Adriamycin-resistant (MCF-7/Adr) and wild-type (MCF-7/wt) human breast cancer cell lines was evaluated with MTT assay. An inhibitory effect on MCF-7/wt cells viability grew stronger with the number of functional units: hexahydroxydiphenoyl (HHDP) group - releasable in the form of ellagic acid (EA), and HHDP derivatives (releasable in the form of EA derivatives). Thus agrimoniin (with five units) was the most active, pedunculagin and rugosin D (with two units each) exhibited medium impact, and rugosin A and tellimagrandin I (both with 1 unit) were the least active. Sanguiin H-6 was the only compound which inhibited MCF-7/Adr cells. It might be hypothesized that the characteristic for sanguiin H-6 structural sanguisorboyl unit contributed to the effect on MCF-7/Adr cells.

引用

页码：122 / 128

页数：7

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