WNT-β-catenin signaling pathway and its relationship with cancer

被引：0

作者：

Berenice Ochoa-Hernandez, Alejandra ^{[1
]}

Ibet Juarez-Vazquez, Clara ^{[2
]}

Alejandra Rosales-Reynoso, Monica ^{[2
]}

Barros-Nunez, Patricio ^{[1
]}

机构：

[1] IMSS, Ctr Invest Biomed Occidente, Div Genet, Guadalajara 44340, Jalisco, Mexico

[2] IMSS, Ctr Invest Biomed Occidente, Div Med Mol, Guadalajara 44340, Jalisco, Mexico

来源：

CIRUGIA Y CIRUJANOS | 2012年 / 80卷 / 04期

关键词：

Wnt; beta-catenin; cancer; diagnosis; prognosis; INHIBITORY FACTOR-I; STEM-CELLS; EPIGENETIC INACTIVATION; PROMOTER METHYLATION; EXPRESSION; TUMOR; DISRUPTION; ACTIVATION; DISEASES; PROTEIN;

D O I：

暂无

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The Wnt-beta-catenin signaling pathway plays a crucial role in the regulation, differentiation, proliferation and cellular death processes; consequently, alterations in this pathway are involved in numerous abnormalities of development, growth and homeostasis in animal organisms. Wnt proteins include a numerous family of secretion glycoproteins that link to Frizzled receptors and low-density lipoprotein receptor-related protein in order to stabilize the critical beta-catenin protein and to initiate an intricate signaling cascade, which is related to multiple nucleocytoplasmic processes. Alterations in the canonical Wnt-beta-catenin signaling pathway have been associated with variations in a number of proteins participating in this route or with activation/inactivation of oncogenes and tumor suppressor genes, explaining different processes of tumorigenesis, in addition to a number of malformations and human diseases. This review describes the relations between the Wnt-beta-catenin signaling pathway with different neoplastic processes as well as its application in the diagnosis and prognosis of cancer.

引用

页码：362 / 370

页数：9

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