COL3A1 and SNAP91: novel glioblastoma markers with diagnostic and prognostic value

被引：47
作者：
Gao, Yuan-Feng [1 ,2 ]
Mao, Xiao-Yuan [1 ,2 ]
Zhu, Tao [1 ,2 ]
Mao, Chen-Xue [1 ,2 ]
Liu, Zhi-Xiong [3 ]
Wang, Zhi-Bin [1 ,2 ]
Li, Ling [1 ,2 ]
Li, Xi [1 ,2 ]
Yin, Ji-Ye [1 ,2 ]
Zhang, Wei [1 ,2 ]
Zhou, Hong-Hao [1 ,2 ]
Liu, Zhao-Qian [1 ,2 ]
机构：
[1] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China
[2] Cent S Univ, Hunan Key Lab Pharmacogenet, Inst Clin Pharmacol, Changsha 410078, Hunan, Peoples R China
[3] Cent S Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China
来源：
ONCOTARGET | 2016年 / 7卷 / 43期
基金：
中国国家自然科学基金;
关键词：
glioblastoma; novel glioblastoma markers; prognostic value; COL3A1; SNAP91; RANDOMIZED PHASE-III; GENE-EXPRESSION; RIBONUCLEOTIDE REDUCTASE; ADJUVANT TEMOZOLOMIDE; EXTRACELLULAR-MATRIX; MALIGNANT GLIOMAS; 5-YEAR ANALYSIS; SURVIVAL; CONCOMITANT; SUBTYPES;
D O I：
10.18632/oncotarget.12038
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Although patients with glioblastoma (GBM) have grave prognosis, significant variability in patient outcome is observed. This study aims to identify novel targets for GBM diagnosis and therapy. Microarray data (GSE4290, GSE7696, and GSE4412) obtained from the Gene Expression Omnibus was used to identify the differentially expressed genes (DEGs) by significant analysis of microarray (SAM). Intersection of the identified DEGs for each profile revealed 46 DEGs in GBM. A subset of common DEGs were validated by real-time reverse transcription quantitative PCR (qPCR). The prognostic value of some of the markers was also studied. We determined that RRM2 and COL3A1 were increased and directly correlated with glioma grade, while SH3GL2 and SNAP91 were decreased in GBM and inversely correlated with glioma grade. Kaplan-Meir analysis of GSE7696 revealed that COL3A1 and SNAP91 correlated with survival, suggesting that COL3A1 and SNAP91 may be suitable biomarkers for diagnostic or therapeutic strategies for GBM.
引用
收藏
页码：70494 / 70503
页数：10
相关论文
共 43 条
  • [21] Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme
    Liang, Y
    Diehn, M
    Watson, N
    Bollen, AW
    Aldape, KD
    Nicholas, MK
    Lamborn, KR
    Berger, MS
    Botstein, D
    Brown, PO
    Israel, MA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (16) : 5814 - 5819
  • [22] Commentary on Effects of Radiotherapy With Concomitant and Adjuvant Temozolomide Versus Radiotherapy Alone on Survival in Glioblastoma in a Randomised Phase III Study: 5-Year Analysis of the EORTC-NCIC Trial (Lancet Oncol. 2009;10:459-466)
    Linz, Ute
    [J]. CANCER, 2010, 116 (08) : 1844 - 1846
  • [23] Variants of COL3A1 Are Associated with the Risk of Stroke Recurrence and Prognosis in the Chinese Population: a Prospective Study
    Lv, Wenfei
    Lin, Yahui
    Song, Weihua
    Sun, Kai
    Yu, Hui
    Zhang, Yinhui
    Zhang, Channa
    Li, Liang
    Suo, Miaomiao
    Hui, Rutai
    Chen, Jingzhou
    [J]. JOURNAL OF MOLECULAR NEUROSCIENCE, 2014, 53 (02) : 196 - 203
  • [24] Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601)
    Mamelak, Adam N.
    Jacoby, Douglas B.
    [J]. EXPERT OPINION ON DRUG DELIVERY, 2007, 4 (02) : 175 - 186
  • [25] Health-Related Quality of Life in Elderly Patients With Newly Diagnosed Glioblastoma Treated With Short-Course Radiation Therapy Plus Concomitant and Adjuvant Temozolomide
    Minniti, Giuseppe
    Scaringi, Claudia
    Baldoni, Alessandra
    Lanzetta, Gaetano
    De Sanctis, Vitaliana
    Esposito, Vincenzo
    Enrici, Riccardo Maurizi
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2013, 86 (02): : 285 - 291
  • [26] Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice
    Morine, Melissa J.
    Toomey, Sinead
    McGillicuddy, Fiona C.
    Reynolds, Clare M.
    Power, Karen A.
    Browne, John A.
    Loscher, Christine
    Mills, Kingston H. G.
    Roche, Helen M.
    [J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2013, 24 (05) : 788 - 795
  • [27] Radiotherapy plus Concomitant Adjuvant Temozolomide for Glioblastoma: Japanese Mono-Institutional Results
    Oike, Takahiro
    Suzuki, Yoshiyuki
    Sugawara, Ken-ichi
    Shirai, Katsuyuki
    Noda, Shin-ei
    Tamaki, Tomoaki
    Nagaishi, Masaya
    Yokoo, Hideaki
    Nakazato, Yoichi
    Nakano, Takashi
    [J]. PLOS ONE, 2013, 8 (11):
  • [28] Glioblastoma and Other Malignant Gliomas A Clinical Review
    Omuro, Antonio
    DeAngelis, Lisa M.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 310 (17): : 1842 - 1850
  • [29] Transmembrane protein CD9 is glioblastoma biomarker, relevant for maintenance of glioblastoma stem cells
    Podergajs, Neza
    Motaln, Helena
    Rajcevic, Uros
    Verbovsek, Urska
    Korsic, Marjan
    Obad, Nina
    Espedal, Heidi
    Vittori, Milos
    Herold-Mende, Christel
    Miletic, Hrvoje
    Bjerkvig, Rolf
    Turnsek, Tamara Lah
    [J]. ONCOTARGET, 2016, 7 (01) : 593 - 609
  • [30] RETRACTED: MicroRNA-330 Is an Oncogenic Factor in Glioblastoma Cells by Regulating SH3GL2 Gene (Retracted Article)
    Qu, Shengtao
    Yao, Yilong
    Shang, Chao
    Xue, Yixue
    Ma, Jun
    Li, Zhen
    Liu, Yunhui
    [J]. PLOS ONE, 2012, 7 (09):
12345