Protective Effect of Naringenin Against Lead-Induced Oxidative Stress in Rats

被引：114
作者：
Wang, Jicang [2 ]
Yang, Zijun [2 ]
Lin, Lin [2 ]
Zhao, Zhanqin [2 ]
Liu, Zongping [1 ]
Liu, Xuezhong [1 ]
机构：
[1] Yangzhou Univ, Coll Vet Med, Yangzhou 225009, Peoples R China
[2] Henan Univ Sci & Technol, Coll Anim Sci & Technol, Luoyang 471003, Peoples R China
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 2012年 / 146卷 / 03期
关键词：
Lead; Naringenin; Oxidative stress; Antioxidants; Liver; Kidney; LIPOIC-ACID; LIPID-PEROXIDATION; FREE-RADICALS; ANTIOXIDANT; QUERCETIN; DAMAGE; LIVER; INHIBITION; METHIONINE; EXPOSURE;
D O I：
10.1007/s12011-011-9268-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxidative stress is thought to be involved in lead-induced toxicity. The aim of this study was to investigate the possible protective role of naringenin on lead-induced oxidative stress in the liver and kidney of rats. In the present investigation, lead acetate (500 mg Pb/L) was administered orally for 8 weeks to induce hepatotoxicity and nephrotoxicity. The levels of hepatic and renal markers such as alanine aminotransferase, aspartate aminotransferase, urea, uric acid, and creatinine were significantly (P < 0.05) increased following lead acetate administration. Lead-induced oxidative stress in liver and kidney tissue was indicated by a significant (P < 0.05) increase in the level of maleic dialdehyde and decreased levels of reduced glutathione, superoxide dismutase, catalase, and glutathione peroxidase. Naringenin markedly attenuated lead-induced biochemical alterations in serum, liver, and kidney tissues (P < 0.05). The present study suggests that naringenin shows antioxidant activity and plays a protective role against lead-induced oxidative damage in the liver and kidney of rats.
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收藏
页码：354 / 359
页数：6
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