Mesenchymal Stem Cells: Emerging Therapy for Duchenne Muscular Dystrophy

被引：39

作者：

Markert, Chad D. ^{[1
,2
]}

Atala, Anthony ^{[2
]}

Cann, Jennifer K. ^{[2
]}

Christ, George ^{[2
]}

Furth, Mark ^{[2
]}

Ambrosio, Fabrisia ^{[3
]}

Childers, Martin K. ^{[1
]}

机构：

[1] Sch Med, Dept Neurol, Winston Salem, NC 27157 USA

[2] Wake Forest Univ Hlth Sci, Wake Forest Inst Regenerat Med, Winston Salem, NC 27157 USA

[3] Univ Pittsburgh, Dept Phys Med & Rehabil, Pittsburgh, PA USA

来源：

PM&R | 2009年 / 1卷 / 06期

关键词：

D O I：

10.1016/j.pmrj.2009.02.013

中图分类号：

R49 [康复医学];

学科分类号：

100215 ;

摘要：

Multipotent cells that can give rise to bone, cartilage, fat, connective tissue, and skeletal and cardiac muscle are termed mesenchymal stem cells. These cells were first identified in the bone marrow, distinct from blood-forming stem cells. Based on the embryologic derivation, availability, and various pro-regenerative characteristics, research exploring their use in cell therapy shows great promise for patients with degenerative muscle diseases and a number of other conditions. In this review, the authors explore the potential for mesenchymal stem cell therapy in the emerging field of regenerative medicine with a focus on treatment for Duchenne muscular dystrophy.

引用

页码：547 / 559

页数：13

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