Ruthenium-Catalyzed C-H Arylation of Benzoic Acids and Indole Carboxylic Acids with Aryl Halides

被引：77

作者：

Simonetti, Marco ^{[1
]}

Cannas, Diego M. ^{[1
]}

Panigrahi, Adyasha ^{[1
]}

Kujawa, Szymon ^{[1
]}

Kryjewski, Michal ^{[2
]}

Xie, Pan ^{[1
]}

Larrosa, Igor ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Oxford Rd, Manchester M13 9PL, Lancs, England

[2] Poznan Univ Med Sci, Dept Inorgan & Analyt Chem, Grunwaldzka 6, PL-60780 Poznan, Poland

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2017年 / 23卷 / 03期

基金：

英国工程与自然科学研究理事会; 欧洲研究理事会;

关键词：

arylation; benzoic acids; C-H activation; indole carboxylic acids; ruthenium; TRACELESS DIRECTING GROUPS; BOND ACTIVATION; ORTHO-AMIDATION; FUNCTIONALIZATION; DECARBOXYLATION; OLEFINATION; STRATEGY; HETEROARYLATION; TRANSFORMATIONS; ALKENYLATION;

D O I：

10.1002/chem.201605068

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein we report the first Ru-catalyzed C-H arylation of benzoic acids with readily available aryl (pseudo)-halides. The reaction, which does not require the use of silver salt additives, allows the arylation of previously challenging hindered benzoic acids and the use of generally unreactive ortho-substituted halorarenes. Furthermore, our new protocol can efficiently be applied to indole carboxylic acids, thus allowing access to C7-, C6-, C5- and C4-arylated indole compounds, a departure from the classical enhanced reactivity of the C2 and C3 positions of indole.

引用

页码：549 / 553

页数：5

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