Zooming in on eukaryotic translation initiation

被引：1

作者：

Liljas, Anders ^{[1
]}

机构：

[1] Lund Univ, Dept Biochem & Struct Biol, Lund, Sweden

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2013年 / 20卷 / 10期

关键词：

START CODON SELECTION; 40S RIBOSOMAL-SUBUNIT; CRYSTAL-STRUCTURE; MESSENGER-RNA; EIF1A; RECOGNITION; FIDELITY; COMPLEX;

D O I：

10.1038/nsmb.2684

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Translation initiation in eukaryotes is a complex and highly regulated process during which several initiation factors cooperate to recruit an initiator tRNA to the small ribosomal subunit, where the mRNA is scanned for an AUG start codon. Two recent reports provide new structural insights into this process and reveal key functions of initiation factors 1 (eIF1) and 1A (eIF1A) in start-codon selection in atomic detail.

引用

收藏

页码：1141 / 1142

页数：2

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