Fluostatins C∼E, novel members of the fluostatin family produced by Streptomyces strain acta 1383

被引：34

作者：

Baur, Stefanie

Niehaus, Joerg

Karagouni, Amalia D.

Katsifas, Efstathios A.

Chalkou, Kalliopi

Meintanis, Christos

Jones, Amanda L.

Goodfellow, Michael

Ward, Alan C.

Beil, Winfried

Schneider, Kathrin

Suessmuth, Roderich D.

Fiedler, Hans-Peter

机构：

[1] Univ Tubingen, Inst Mikrobiol, D-72076 Tubingen, Germany

[2] Univ Athens, Fac Biol, Dept Bot, Athens 15781, Greece

[3] Univ Newcastle, Div Biol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[4] Hannover Med Sch, Inst Pharmakol, D-30625 Hannover, Germany

[5] Tech Univ Berlin, Inst Chem, FG Organ Chem, D-10623 Berlin, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2006年 / 59卷 / 05期

关键词：

Streptomyces; taxonomy; fermentation; novel fluostatins;

D O I：

10.1038/ja.2006.41

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Three new members of the fluostatin family, fluostatins C-E. were discovered in a culture filtrate extract of strain Acta 1383 during an HPLC screening program. The producing strain belongs to the genus Streptom.Vces and is closely related to type strains classified in the Streptomyces lavendulae 16S rRNA subclade. Fluostatins are named by their characteristic fluorenone chromophore. Fluostatin C shows moderate activity against selected human tumor cell lines.

引用

页码：293 / 297

页数：5

共 17 条

[1] Fluostatins A and B, new inhibitors of dipeptidyl peptidase III, produced by Streptomyces sp. TA-3391 -: I.: Taxonomy of producing strain, production, isolation, physico-chemical properties and biological properties [J].