The interaction of native DNA with iron(III)-N,N′-ethylene-bis(salicylideneiminato)-chloride

被引：145

作者：

Silvestri, A ^{[1
]}

Barone, G ^{[1
]}

Ruisi, G ^{[1
]}

Lo Giudice, MT ^{[1
]}

Tumminello, S ^{[1
]}

机构：

[1] Univ Palermo, Dipartimento Chim Inorgan & Analit S Cannizzaro, I-90128 Palermo, Italy

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2004年 / 98卷 / 04期

关键词：

DNA; iron(III); Schiff bases; Salen;

D O I：

10.1016/j.jinorgbio.2004.01.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction between native calf thymus deoxyribonucleic acid (DNA) and Fe-III-N,N'-ethylene-bis (salicylideneiminato)chloride, Fe(Salen)Cl, was investigated in aqueous solutions by UV-visible (UV-vis) absorption, circular clichroisin (CD), thermal denaturation and viscosity measurements. The results obtained from CD, UV-vis and viscosity measurements exclude DNA intercalation and can be interpreted in terms of an electrostatic binding between the Fe(Salen)(+) cation and the phosphate groups of DNA. The trend of the UV-vis absorption band of the Fe(Salen)Cl complex at different ratios [DNA(phosphate)]/[Fe(Salen)Cl] and the large increase of the melting temperature of DNA in the presence of Fe(Salen)Cl, support the hypothesis of an external electrostatic interaction between the negatively charged DNA double helix and the axially stacked positively charged Fe(Salen)(+) moieties, analogously to what reported for a number of porphyrazines and metal-porphyrazine complexes interacting with DNA. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：589 / 594

页数：6

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