MOLECULAR AND GENETIC DETERMINANTS OF ALCOHOL DEPENDENCE

被引：4

作者：

Awofala, Awoyemi A. ^{[1
]}

机构：

[1] Tai Solarin Univ Educ, Dept Biol Sci, Ijagun, Ogun State, Nigeria

来源：

JOURNAL OF ADDICTIVE DISEASES | 2013年 / 32卷 / 03期

关键词：

Alcohol dependence; genes; linkage; epigenetics; association studies; microarray; CHRONIC ETHANOL-CONSUMPTION; GENOME-WIDE ASSOCIATION; NMDA RECEPTOR; SUBSTANCE DEPENDENCE; NUCLEUS-ACCUMBENS; GABA-A; EXPRESSION; RAT; TOLERANCE; LOCI;

D O I：

10.1080/10550887.2013.824329

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Alcohol dependence is a complex disorder affecting all social and ethnic groups. Although the scientific understanding of the mechanism governing this multifactorial disease is still in its infancy, understanding its biological bases, including the potential contribution of genetic factors, is key to characterizing individual's risk and developing efficacious therapeutic target to combat the disease. This review provides an overview of different approaches that are being increasingly integrated to extend our knowledge of the genetic underpinnings of alcohol dependence.

引用

页码：293 / 309

页数：17

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