SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network

被引：188

作者：

Li, Xuefei ^{[1
]}

Xu, Yingxi ^{[1
]}

Chen, Yanan ^{[1
]}

Chen, Si ^{[1
,2
]}

Jia, Xianpei ^{[1
]}

Sun, Tongchao ^{[1
]}

Liu, Yanhua ^{[1
]}

Li, Xiru ^{[3
]}

Xiang, Rong ^{[1
,4
]}

Li, Na ^{[1
,4
]}

机构：

[1] Nankai Univ, Sch Med, Tianjin 300071, Peoples R China

[2] US FDA, Div Biochem Toxicol, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA

[3] Chinese Peoples Liberat Army Gen Hosp, Dept Gen Surg, Beijing 100853, Peoples R China

[4] Tianjin Key Lab Tumor Microenvironm & Neurovasc R, Tianjin 300071, Peoples R China

来源：

CANCER LETTERS | 2013年 / 336卷 / 02期

关键词：

SOX2; Tumor metastasis; EMT; beta-catenin; TGF-beta; 1; BREAST-CANCER CELLS; STEM-CELLS; E-CADHERIN; TIGHT JUNCTIONS; EXPRESSION; PLURIPOTENCY; MECHANISMS; INVASION; PATHWAY; TRAITS;

D O I：

10.1016/j.canlet.2013.03.027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

SOX2 was reported to promote metastasis in various tumor tissues; however the underlying mechanisms remain elusive. Here, we disclosed that SOX2 improves metastasis of breast and prostate cancer cells by promoting epithelial-to-mesenchymal transition (EMT) through WNT/beta-catenin, but not TGF-beta or Snaill signaling. Dual luciferase assay and chromatin immunoprecipitation revealed activation and binding of SOX2 on promoter region of beta-catenin. In addition, SOX2 affects the protein expression levels of DKK3, DVL1 and DVL3, which are regulators or downstream molecules of WNT signaling. Taken together, our findings demonstrated beta-catenin as one of vital downstream molecules that mediate the EMT induced by SOX2. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：379 / 389

页数：11

共 39 条

[1] Wnt/β-catenin signaling [J].

Akiyama, T .

CYTOKINE & GROWTH FACTOR REVIEWS, 2000, 11 (04) :273-282

[2] The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation [J].

Beavon, IRG .

EUROPEAN JOURNAL OF CANCER, 2000, 36 (13) :1607-1620

[3] Epithelial mesenchymal transition traits in human breast cancer cell lines [J].

Blick, T. ;

Widodo, E. ;

Hugo, H. ;

Waltham, M. ;

Lenburg, M. E. ;

Neve, R. M. ;

Thompson, E. W. .

CLINICAL & EXPERIMENTAL METASTASIS, 2008, 25 (06) :629-642

[4] Opinion - Migrating cancer stem cells - an integrated concept of malignant tumour progression [J].

Brabletz, T ;

Jung, A ;

Spaderna, S ;

Hlubek, F ;

Kirchner, T .

NATURE REVIEWS CANCER, 2005, 5 (09) :744-749

[5] The ins and outs of E-cadherin trafficking [J].

Bryant, DM ;

Stow, JL .

TRENDS IN CELL BIOLOGY, 2004, 14 (08) :427-434

[6]

Chen SS, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0036784, 10.1371/journal.pone.0049275, 10.1371/journal.pone.0045763, 10.1371/journal.pone.0050456]

[7] The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer [J].