Base Editors and Off-Targeting: The Deaminase Matters

被引:1
作者
Willmann, Matthew R. [1 ]
机构
[1] Cornell Univ, Plant Transformat Facil, Sch Integrat Plant Sci, Ithaca, NY 14853 USA
来源
CRISPR JOURNAL | 2019年 / 2卷 / 02期
关键词
GENOMIC DNA;
D O I
10.1089/crispr.2019.29054.mrw
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
引用
收藏
页码:71 / 73
页数:3
相关论文
共 50 条
[21]   Base Editors for Citrus Gene Editing [J].
Huang, Xiaoen ;
Wang, Yuanchun ;
Wang, Nian .
FRONTIERS IN GENOME EDITING, 2022, 4
[22]   Base editors: development and applications in biomedicine [J].
Liang, Yanhui ;
Chen, Fangbing ;
Wang, Kepin ;
Lai, Liangxue .
FRONTIERS OF MEDICINE, 2023, 17 (03) :359-387
[23]   Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity [J].
Yu, Yi ;
Leete, Thomas C. ;
Born, David A. ;
Young, Lauren ;
Barrera, Luis A. ;
Lee, Seung-Joo ;
Rees, Holly A. ;
Ciaramella, Giuseppe ;
Gaudelli, Nicole M. .
NATURE COMMUNICATIONS, 2020, 11 (01)
[24]   Adenine base editors induce off-target structure variations in mouse embryos and primary human T cells [J].
Wu, Leilei ;
Jiang, Shutan ;
Shi, Meisong ;
Yuan, Tanglong ;
Li, Yaqin ;
Huang, Pinzheng ;
Li, Yingqi ;
Zuo, Erwei ;
Zhou, Changyang ;
Sun, Yidi .
GENOME BIOLOGY, 2024, 25 (01)
[25]   Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors [J].
Grunewald, Julian ;
Zhou, Ronghao ;
Garcia, Sara P. ;
Iyer, Sowmya ;
Lareau, Caleb A. ;
Aryee, Martin J. ;
Joung, J. Keith .
NATURE, 2019, 569 (7756) :433-+
[26]   Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope [J].
Bamidele, Nathan ;
Zhang, Han ;
Dong, Xiaolong ;
Cheng, Haoyang ;
Gaston, Nicholas ;
Feinzig, Hailey ;
Cao, Hanbing ;
Kelly, Karen ;
Watts, Jonathan K. ;
Xie, Jun ;
Gao, Guangping ;
Sontheimer, Erik J. .
NATURE COMMUNICATIONS, 2024, 15 (01)
[27]   A Taxonomic and Phylogenetic Classification of Diverse Base Editors [J].
Nguyen Tran, Minh Thuan ;
Kc, Rajendra ;
Hewitt, Alex W. .
CRISPR JOURNAL, 2022, 5 (02) :311-328
[28]   Efforts to Downsize Base Editors for Clinical Applications [J].
Song, Beomjong .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 26 (05)
[29]   Risk Prediction of RNA Off-Targets of CRISPR Base Editors in Tissue-Specific Transcriptomes Using Language Models [J].
Nakamae, Kazuki ;
Suzuki, Takayuki ;
Yonezawa, Sora ;
Yamamoto, Kentaro ;
Kakuzaki, Taro ;
Ono, Hiromasa ;
Naito, Yuki ;
Bono, Hidemasa .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 26 (04)
[30]   Simplified adenine base editors improve adenine base editing efficiency in rice [J].
Hua, Kai ;
Tao, Xiaoping ;
Liang, Weiyi ;
Zhang, Zhaoxia ;
Gou, Runyu ;
Zhu, Jian-Kang .
PLANT BIOTECHNOLOGY JOURNAL, 2020, 18 (03) :770-778