Base Editors and Off-Targeting: The Deaminase Matters

被引：1

作者：

Willmann, Matthew R. ^{[1
]}

机构：

[1] Cornell Univ, Plant Transformat Facil, Sch Integrat Plant Sci, Ithaca, NY 14853 USA

来源：

CRISPR JOURNAL | 2019年 / 2卷 / 02期

关键词：

GENOMIC DNA;

D O I：

10.1089/crispr.2019.29054.mrw

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

引用

页码：71 / 73

页数：3

共 14 条

[1] Programmable base editing of A.T to G.C in genomic DNA without DNA cleavage [J].

Gaudelli, Nicole M. ;

Komor, Alexis C. ;

Rees, Holly A. ;

Packer, Michael S. ;

Badran, Ahmed H. ;

Bryson, David I. ;

Liu, David R. .

NATURE, 2017, 551 (7681) :464-+

[2] An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities [J].

Gehrke, Jason M. ;

Cervantes, Oliver ;

Clement, M. Kendell ;

Wu, Yuxuan ;

Zeng, Jing ;

Bauer, Daniel E. ;

Pinello, Luca ;

Joung, J. Keith .

NATURE BIOTECHNOLOGY, 2018, 36 (10) :977-+

[3] RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators [J].

Harris, RS ;

Petersen-Mahrt, SK ;

Neuberger, MS .

MOLECULAR CELL, 2002, 10 (05) :1247-1253

[4] Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice [J].

Jin, Shuai ;

Zong, Yuan ;

Gao, Qiang ;

Zhu, Zixu ;

Wang, Yanpeng ;

Qin, Peng ;

Liang, Chengzhi ;

Wang, Daowen ;

Qiu, Jin-Long ;

Zhang, Feng ;

Gao, Caixia .

SCIENCE, 2019, 364 (6437) :292-+

[5] Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage [J].

Komor, Alexis C. ;

Kim, Yongjoo B. ;

Packer, Michael S. ;

Zuris, John A. ;

Liu, David R. .

NATURE, 2016, 533 (7603) :420-+

[6] Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing [J].

Liu, Zhen ;

Lu, Zongyang ;

Yang, Guang ;

Huang, Shisheng ;

Li, Guanglei ;

Feng, Songjie ;

Liu, Yajing ;

Li, Jianan ;

Yu, Wenxia ;

Zhang, Yu ;

Chen, Jia ;

Sun, Qiang ;

Huang, Xingxu .

NATURE COMMUNICATIONS, 2018, 9

[7] A robust and high-throughput Cre reporting and characterization system for the whole mouse brain [J].

Madisen, Linda ;

Zwingman, Theresa A. ;

Sunkin, Susan M. ;

Oh, Seung Wook ;

Zariwala, Hatim A. ;

Gu, Hong ;

Ng, Lydia L. ;

Palmiter, Richard D. ;

Hawrylycz, Michael J. ;

Jones, Allan R. ;

Lein, Ed S. ;

Zeng, Hongkui .

NATURE NEUROSCIENCE, 2010, 13 (01) :133-U311

[8] Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems [J].

Nishida, Keiji ;

Arazoe, Takayuki ;

Yachie, Nozomu ;

Banno, Satomi ;

Kakimoto, Mika ;

Tabata, Mayura ;

Mochizuki, Masao ;

Miyabe, Aya ;

Araki, Michihiro ;

Hara, Kiyotaka Y. ;

Shimatani, Zenpei ;

Kondo, Akihiko .

SCIENCE, 2016, 353 (6305)

[9] Increased spontaneous mutation frequency in human cells expressing the phage PBS2-encoded inhibitor of uracil-DNA glycosylase [J].

Radany, EH ;

Dornfeld, KJ ;

Sanderson, RJ ;

Savage, MK ;

Majumdar, A ;

Seidman, MM ;

Mosbaugh, DW .

MUTATION RESEARCH-DNA REPAIR, 2000, 461 (01) :41-58

[10]

Rees HA, 2018, NAT REV GENET, V19, P770, DOI 10.1038/s41576-018-0059-1

← 1 2 →