Cellular transduction mechanisms of adeno-associated viral vectors

被引：48
|
作者：
Berry, Garrett Edward [1 ,2 ,3 ]
Asokan, Aravind [1 ,2 ,4 ]
机构：
[1] Univ N Carolina, Gene Therapy Ctr, Chapel Hill, NC 27514 USA
[2] Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
[3] Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC USA
[4] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27514 USA
来源：
CURRENT OPINION IN VIROLOGY | 2016年 / 21卷
关键词：
HIGH-EFFICIENCY TRANSDUCTION; VIRUS CAPSID PROTEINS; TYROSINE-PHOSPHORYLATION; TRANSGENE EXPRESSION; INTRACELLULAR TRAFFICKING; MRE11/RAD50/NBS1; COMPLEX; 2ND-STRAND SYNTHESIS; HUMAN-CELLS; ER STRESS; WILD-TYPE;
D O I：
10.1016/j.coviro.2016.08.001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Recombinant adeno-associated viral vectors (rAAV) are regarded as promising vehicles for therapeutic gene delivery. Continued development and new strategies are essential to improve the potency of AAV vectors and reduce the effective dose needed for clinical efficacy. In this regard, many studies have focused on understanding the cellular transduction mechanisms of rAAV, often with the goal of exploiting this knowledge to increase gene transfer efficiency. Here, we provide an overview of our evolving understanding of rAAV cellular trafficking pathways through the host cell, beginning with cellular entry and ending with transcription of the vector genome. Strategies to exploit this information for improving rAAV transduction are discussed.
引用
收藏
页码：54 / 60
页数：7
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