Transplantation of neural stem cells into explants of rat inner ear

被引:8
作者
Fujino, K [1 ]
Kim, TS [1 ]
Nishida, AT [1 ]
Nakagawa, T [1 ]
Omori, K [1 ]
Naito, Y [1 ]
Ito, J [1 ]
机构
[1] Kyoto Univ, Dept Otolaryngol Head & Neck Surg, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan
关键词
balance disorders; hair cell; hearing loss; organ culture;
D O I
10.1080/03655230310016717
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Damage and loss of hair cells in the inner ear is the most frequent cause of hearing loss and balance disorders. Mammalian hair cells do not regenerate in the conventional ways. To regenerate the hair cell in the mammalian inner ear we transplanted neural stem cells into explants of rat inner ear. The stem cells integrated successfully into the sensory epithelium of the vestibular organs. but not into the organ of Corti. This method is useful to investigate efficient ways to transplant stem cells into the inner ear.
引用
收藏
页码:31 / 33
页数:3
相关论文
共 15 条
[1]   Neuronal differentiation of adult rat hippocampus-derived neural stem cells transplanted into embryonic rat explanted retinas with retinoic acid pretreatment [J].
Akita, J ;
Takahashi, M ;
Hojo, M ;
Nishida, A ;
Haruta, M ;
Honda, Y .
BRAIN RESEARCH, 2002, 954 (02) :286-293
[2]   REGENERATION OF SENSORY HAIR-CELLS AFTER ACOUSTIC TRAUMA [J].
CORWIN, JT ;
COTANCHE, DA .
SCIENCE, 1988, 240 (4860) :1772-1774
[3]   A SELF-RENEWING MULTIPOTENTIAL STEM-CELL IN EMBRYONIC RAT CEREBRAL-CORTEX [J].
DAVIS, AA ;
TEMPLE, S .
NATURE, 1994, 372 (6503) :263-266
[4]   Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry [J].
Englund, U ;
Björklund, A ;
Wictorin, K ;
Lindvall, O ;
Kokaia, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (26) :17089-17094
[5]   ULTRASTRUCTURAL EVIDENCE FOR HAIR CELL REGENERATION IN THE MAMMALIAN INNER-EAR [J].
FORGE, A ;
LI, L ;
CORWIN, JT ;
NEVILL, G .
SCIENCE, 1993, 259 (5101) :1616-1619
[6]  
Ito J, 2001, ACTA OTO-LARYNGOL, V121, P140
[7]   Transplantation of adult rat hippocampus-derived neural stem cells into retina injured by transient ischemia [J].
Kurimoto, Y ;
Shibuki, H ;
Kaneko, Y ;
Ichikawa, M ;
Kurokawa, T ;
Takahashi, M ;
Yoshimura, N .
NEUROSCIENCE LETTERS, 2001, 306 (1-2) :57-60
[8]   Notch signalling pathway mediates hair cell development in mammalian cochlea [J].
Lanford, PJ ;
Lan, Y ;
Jiang, RL ;
Lindsell, C ;
Weinmaster, G ;
Gridley, T ;
Kelley, MW .
NATURE GENETICS, 1999, 21 (03) :289-292
[9]   RETINOIC ACID STIMULATES REGENERATION OF MAMMALIAN AUDITORY HAIR-CELLS [J].
LEFEBVRE, PP ;
MALGRANGE, B ;
STAECKER, H ;
MOONEN, G ;
VANDEWATER, TR .
SCIENCE, 1993, 260 (5108) :692-695
[10]   Electrophysiological properties of vestibular sensory and supporting cells in the labyrinth slice before and during regeneration [J].
Masetto, S ;
Correia, MJ .
JOURNAL OF NEUROPHYSIOLOGY, 1997, 78 (04) :1913-1927