BBOX1 promotes triple-negative breast cancer progression by controlling IP3R3 stability

被引：7
|
作者：
Liao, Chengheng [1 ]
Zhang, Qing [1 ]
机构：
[1] Univ Texas Southwestern Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2020年 / 7卷 / 06期
关键词：
TNBC; 2-OG dependent enzyme; therapeutic target;
D O I：
10.1080/23723556.2020.1813526
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Limited therapeutic options impede the clinical outcome of triple-negative breast cancer (TNBC). Our recent study uncovered a novel signaling pathway implicating gamma-butyrobetaine hydroxylase 1 (BBOX1) in the control of cell growth in TNBC, via inositol 1, 4, 5-trisphosphate receptor type 3 (IP3R3) mediated calcium signaling which is essential for cellular energy metabolism.
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页数：3
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