Advance in research of microRNA in Caenorhabditis elegans

被引：3

作者：

Liu, Jing ^{[1
]}

Yang, Baofeng ^{[1
]}

Ai, Jing ^{[1
]}

机构：

[1] Harbin Med Univ, Dept Pharmacol, State Prov Key Labs Biomed Pharmaceut China, Key Lab Cardiovasc Res,Minist Educ, Harbin 150081, Peoples R China

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2013年 / 114卷 / 05期

基金：

中国国家自然科学基金;

关键词：

microRNAs; Caenorhabditis elegans; DEVELOPMENT; LIFESPAN; HUMAN DISEASE; RESTRICTION-INDUCED LONGEVITY; C-ELEGANS; GENE-EXPRESSION; LIFE-SPAN; OXIDATIVE STRESS; BREAST-CANCER; SMALL RNAS; LET-7; NEMATODE; FAMILY;

D O I：

10.1002/jcb.24448

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

microRNA (miRNA) is a family of small, non-coding RNA first discovered as an important regulator of development in Caenorhabditis elegans (C. elegans). Numerous miRNAs have been found in C. elegans, and some of them are well conserved in many organisms. Though, the biologic function of miRNAs in C. elegans was largely unknown, more and more studies support the idea that miRNA is an important molecular for C. elegans. In this review, we revisit the research progress of miRNAs in C. elegans related with development, aging, cancer, and neurodegenerative diseases and compared the function of miRNAs between C. elegans and human. J. Cell. Biochem. 114: 9941000, 2013. (c) 2012 Wiley Periodicals, Inc.

引用

页码：994 / 1000

页数：7

共 73 条

[1] The let-7 microRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans [J].