Brain-gut-microbiome interactions in obesity and food addiction
被引:161
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作者:
Gupta, Arpana
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Univ Calif Los Angeles, Ingest Behav & Obes Program, G Oppenheimer Family Ctr Neurobiol Stress & Resil, Los Angeles, CA 90032 USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Vatche & Tamar Manoukian Div Digest Dis, Los Angeles, CA 90032 USAUniv Calif Los Angeles, Ingest Behav & Obes Program, G Oppenheimer Family Ctr Neurobiol Stress & Resil, Los Angeles, CA 90032 USA
Gupta, Arpana
[1
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,3
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Osadchiy, Vadim
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Univ Calif Los Angeles, Ingest Behav & Obes Program, G Oppenheimer Family Ctr Neurobiol Stress & Resil, Los Angeles, CA 90032 USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Ingest Behav & Obes Program, G Oppenheimer Family Ctr Neurobiol Stress & Resil, Los Angeles, CA 90032 USA
Osadchiy, Vadim
[1
,2
]
Mayer, Emeran A.
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h-index: 0
机构:
Univ Calif Los Angeles, Ingest Behav & Obes Program, G Oppenheimer Family Ctr Neurobiol Stress & Resil, Los Angeles, CA 90032 USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Vatche & Tamar Manoukian Div Digest Dis, Los Angeles, CA 90032 USA
Univ Calif Los Angeles, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA 90032 USAUniv Calif Los Angeles, Ingest Behav & Obes Program, G Oppenheimer Family Ctr Neurobiol Stress & Resil, Los Angeles, CA 90032 USA
Mayer, Emeran A.
[1
,2
,3
,4
]
机构:
[1] Univ Calif Los Angeles, Ingest Behav & Obes Program, G Oppenheimer Family Ctr Neurobiol Stress & Resil, Los Angeles, CA 90032 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Vatche & Tamar Manoukian Div Digest Dis, Los Angeles, CA 90032 USA
[4] Univ Calif Los Angeles, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA 90032 USA
Normal eating behaviour is coordinated by the tightly regulated balance between intestinal and extra-intestinal homeostatic and hedonic mechanisms. By contrast, food addiction is a complex, maladaptive eating behaviour that reflects alterations in brain-gut-microbiome (BGM) interactions and a shift of this balance towards hedonic mechanisms. Each component of the BGM axis has been implicated in the development of food addiction, with both brain to gut and gut to brain signalling playing a role. Early-life influences can prime the infant gut microbiome and brain for food addiction, which might be further reinforced by increased antibiotic usage and dietary patterns throughout adulthood. The ubiquitous availability and marketing of inexpensive, highly palatable and calorie-dense food can further shift this balance towards hedonic eating through both central (disruptions in dopaminergic signalling) and intestinal (vagal afferent function, metabolic endotoxaemia, systemic immune activation, changes to gut microbiome and metabolome) mechanisms. In this Review, we propose a systems biology model of BGM interactions, which incorporates published reports on food addiction, and provides novel insights into treatment targets aimed at each level of the BGM axis. Food addiction is an eating behaviour that reflects alterations in brain-gut-microbiome (BGM) interactions and a shift towards hedonic mechanisms. This Review summarizes the physiology of food addiction in obesity as it relates to BGM interactions and provides insights into treatment targets for food addiction aimed at each level of the BGM axis.
机构:
Univ North Carolina Chapel Hill, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USAUniv North Carolina Chapel Hill, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA
Chi, Liang
Mahbub, Ridwan
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Univ Georgia, Dept Environm Hlth Sci, Athens, GA 30602 USAUniv North Carolina Chapel Hill, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA
Mahbub, Ridwan
Gao, Bei
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机构:
Univ North Carolina Chapel Hill, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USAUniv North Carolina Chapel Hill, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA
Gao, Bei
Bian, Xiaoming
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机构:
Univ North Carolina Chapel Hill, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USAUniv North Carolina Chapel Hill, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA
Bian, Xiaoming
Tu, Pengcheng
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Univ North Carolina Chapel Hill, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USAUniv North Carolina Chapel Hill, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA
Tu, Pengcheng
Ru, Hongyu
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机构:
North Carolina State Univ, Dept Populat Hlth & Pathobiol, Raleigh, NC 27606 USAUniv North Carolina Chapel Hill, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA
Ru, Hongyu
Lu, Kun
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机构:
Univ North Carolina Chapel Hill, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USAUniv North Carolina Chapel Hill, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA
机构:
Cedars Sinai Med Ctr, Med Associated Sci & Technol MAST Program, Los Angeles, CA 90048 USACedars Sinai Med Ctr, Med Associated Sci & Technol MAST Program, Los Angeles, CA 90048 USA
Singer-Englar, Tahli
Barlow, Gillian
论文数: 0引用数: 0
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Cedars Sinai Med Ctr, Med Associated Sci & Technol MAST Program, Los Angeles, CA 90048 USACedars Sinai Med Ctr, Med Associated Sci & Technol MAST Program, Los Angeles, CA 90048 USA
Barlow, Gillian
Mathur, Ruchi
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Cedars Sinai Med Ctr, Med Associated Sci & Technol MAST Program, Los Angeles, CA 90048 USACedars Sinai Med Ctr, Med Associated Sci & Technol MAST Program, Los Angeles, CA 90048 USA
机构:
State Univ Sao Paulo UNESP, Dept Food & Nutr, Sch Pharmaceut Sci, Araraquara, SP, BrazilState Univ Sao Paulo UNESP, Dept Food & Nutr, Sch Pharmaceut Sci, Araraquara, SP, Brazil
Bianchi, Fernanda
Rocha Faria Duque, Ana Luiza
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State Univ Sao Paulo UNESP, Dept Food & Nutr, Sch Pharmaceut Sci, Araraquara, SP, BrazilState Univ Sao Paulo UNESP, Dept Food & Nutr, Sch Pharmaceut Sci, Araraquara, SP, Brazil
Rocha Faria Duque, Ana Luiza
Isay Saad, Susana Marta
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Univ Sao Paulo, Dept Biochem & Pharmaceut Technol, Sao Paulo, SP, Brazil
Univ Sao Paulo, Food Res Ctr, Sao Paulo, SP, BrazilState Univ Sao Paulo UNESP, Dept Food & Nutr, Sch Pharmaceut Sci, Araraquara, SP, Brazil
Isay Saad, Susana Marta
Sivieri, Katia
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State Univ Sao Paulo UNESP, Dept Food & Nutr, Sch Pharmaceut Sci, Araraquara, SP, BrazilState Univ Sao Paulo UNESP, Dept Food & Nutr, Sch Pharmaceut Sci, Araraquara, SP, Brazil
机构:
Univ Paris Saclay, AgroParisTech, INRA, Inst Micalis, Jouy En Josas, FranceUniv Paris Saclay, AgroParisTech, INRA, Inst Micalis, Jouy En Josas, France