Uvaridacols E-H, Highly Oxygenated Antiausterity Agents from Uvaria dac

被引：21

作者：

Awale, Suresh ^{[1
,2
]}

Ueda, Jun-ya ^{[1
,2
]}

Athikomkulchai, Sirivan ^{[3
]}

Dibwe, Dya Fita ^{[2
]}

Abdelhamed, Sherif ^{[2
]}

Yokoyama, Satoru ^{[2
]}

Saiki, Ikuo ^{[2
]}

Miyatake, Ryuta ^{[4
]}

机构：

[1] Toyama Univ, Frontier Res Core Life Sci, Toyama 9300194, Japan

[2] Toyama Univ, Inst Nat Med, Toyama 9300194, Japan

[3] Srinakharinwirot Univ, Fac Pharm, Nakhon Nayok 26120, Thailand

[4] Toyama Univ, Grad Sch Sci & Engn, Toyama 9308555, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 11期

关键词：

CANCER-CELL-LINES; SECONDARY METABOLITES; CYTOTOXIC ACTIVITY; ANTICANCER AGENTS; KAYEA-ASSAMICA; TOLERANCE; PANC-1; IDENTIFICATION; ELIMINATE; FLOWER;

D O I：

10.1021/np300596c

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical investigation of the stems of Uvaria dac yielded four new highly oxygenated cyclohexene derivatives named uvaridacols E-H (1-4). Their structures were established through NMR and circular dichroism spectroscopic analysis Uvaridacols E (1), F (2), and H (4) displayed weak preferential cytotordcity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions in a concentration-dependent manner, without causing toxicity in normal nutrient-rich conditions.

引用

页码：1999 / 2002

页数：4

共 15 条

[1]

[Anonymous], 2012, Comprehensive Chiroptical Spectroscopy, DOI DOI 10.1002/9781118120392.CH4

[2] Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation [J].

Awale, S ;

Lu, J ;

Kalauni, SK ;

Kurashima, Y ;

Tezuka, Y ;

Kadota, S ;

Esumi, H .

CANCER RESEARCH, 2006, 66 (03) :1751-1757

[3] Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation [J].

Awale, S ;

Nakashima, EMN ;

Kalauni, SK ;

Tezuka, Y ;

Kurashima, Y ;

Lu, J ;

Esumi, H ;

Kadota, S .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (03) :581-583

[4] Antiausterity Agents from Uvaria dac and Their Preferential Cytotoxic Activity against Human Pancreatic Cancer Cell Lines in a Nutrient-Deprived Condition [J].

Awale, Suresh ;

Ueda, Jun-ya ;

Athikomkulchai, Sirivan ;

Abdelhamed, Sherif ;

Yokoyama, Satoru ;

Saiki, Ikuo ;

Miyatake, Ryuta .

JOURNAL OF NATURAL PRODUCTS, 2012, 75 (06) :1177-1183

[5] Identification of Chrysoplenetin from Vitex negundo as a Potential Cytotoxic Agent against PANC-1 and a Panel of 39 Human Cancer Cell Lines (JFCR-39) [J].

Awale, Suresh ;

Linn, Thein Zaw ;

Li, Feng ;

Tezuka, Yasuhiro ;

Myint, Aung ;

Tomida, Akihiro ;

Yamori, Takao ;

Esumi, Hiroyasu ;

Kadota, Shigetoshi .

PHYTOTHERAPY RESEARCH, 2011, 25 (12) :1770-1775

[6] Cytotoxic Constituents of Soymida febrifuga from Myanmar [J].

Awale, Suresh ;

Miyamoto, Tatsuya ;

Linn, Thein Zaw ;

Li, Feng ;

Win, Nwet Nwet ;

Tezuka, Yasuhiro ;

Esumi, Hiroyasu ;

Kadota, Shigetoshi .

JOURNAL OF NATURAL PRODUCTS, 2009, 72 (09) :1631-1636

[7]

ELTAWIL KM, 2012, J HEPATOBILIARY PANC, V14, P260, DOI DOI 10.1111/J.1477-2574.2012.00441.X

[8]

Izuishi K, 2000, CANCER RES, V60, P6201

[9] Study on the Constituents of Mexican Propolis and Their Cytotoxic Activity against PANC-1 Human Pancreatic Cancer Cells [J].

Li, Feng ;

Awale, Suresh ;

Tezuka, Yasuhiro ;

Esmi, Hiroyasu ;

Kadota, Shigetoshi .

JOURNAL OF NATURAL PRODUCTS, 2010, 73 (04) :623-627

[10] Kigamicin D, a novel anticancer agent based on a new anti-austerity strategy targeting cancer cells' tolerance to nutrient starvation [J].

Lu, J ;

Kunimoto, S ;

Yamazaki, Y ;

Kaminishi, M ;

Esumi, H .

CANCER SCIENCE, 2004, 95 (06) :547-552

← 1 2 →