Metal-Catalyzed Decarboxylative Fluoroalkylation Reactions

被引：14
作者：
Ambler, Brett R. [1 ]
Yang, Ming-Hsiu [1 ]
Altman, Ryan A. [1 ]
机构：
[1] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA
来源：
SYNLETT | 2016年 / 27卷 / 20期
关键词：
fluorine; trifluoromethylation; difluoroketone; decarboxylation; catalysis; copper; palladium; NUCLEOPHILIC TRIFLUOROMETHYLATION; MEDIATED TRIFLUOROMETHYLATION; STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC-SYNTHESIS; UNIQUE REACTIVITIES; ALLYLIC ALKYLATION; ORGANIC HALIDES; ALPHA-ARYLATION; INNER-SPHERE; KETONES;
D O I：
10.1055/s-0036-1588637
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Metal-catalyzed decarboxylative fluoroalkylation reactions enable the conversion of simple O-based substrates into biologically relevant fluorinated analogues. Herein, we present decarboxylative methods that facilitate the synthesis of trifluoromethyl-and difluoroketonecontaining products. We highlight key mechanistic aspects that are critical for efficient catalysis, and that inspired our thinking while developing the reactions.
引用
收藏
页码：2747 / 2755
页数：9
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