"Clickable" Hydrosoluble PEGylated Cryptophane as a Universal Platform for 129Xe Magnetic Resonance Imaging Biosensors

被引：16
作者：
Delacour, Lea [1 ]
Kotera, Naoko [1 ]
Traore, Tenin [1 ]
Garcia-Argote, Sebastien [1 ]
Puente, Celine [1 ]
Leteurtre, Francois [2 ]
Gravel, Edmond [1 ]
Tassali, Nawal [3 ]
Boutin, Celine [3 ]
Leonce, Estelle [3 ]
Boulard, Yves [2 ]
Berthault, Patrick [3 ]
Rousseau, Bernard [1 ]
机构：
[1] CEA, SCBM, IBiTecS, F-91191 Gif Sur Yvette, France
[2] CEA, IBiTecS, Serv Biol Integrat & Genet Mol SBIGeM, F-91191 Gif Sur Yvette, France
[3] CEA, Lab Struct & Dynam Resonance Magnet, Serv Interdisciplinaire Syst Mol & Mat SIS2M, IRAMIS, F-91191 Gif Sur Yvette, France
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 19期
关键词：
biosensors; cage compounds; click chemistry; cryptophane; NMR spectroscopy; xenon; WATER-SOLUBLE CRYPTOPHANES; HUMAN CARBONIC-ANHYDRASE; NMR-BASED BIOSENSORS; XENON BIOSENSOR; FUNCTIONALIZED XENON; TERMINAL ALKYNES; ENCAPSULATION; SENSITIVITY; AFFINITY; AZIDES;
D O I：
10.1002/chem.201204218
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We describe the synthesis of a highly water-soluble cryptophane 1 that can be seen as a universal platform for the construction of Xe-129 magnetic resonance imaging (MRI)-based biosensors. Compound 1 is easily functionalized by Huisgen cycloaddition and exhibits excellent xenon-encapsulation properties. In addition, 1 is nontoxic at the concentrations typically used for hyperpolarized Xe-129 MRI.
引用
收藏
页码：6089 / 6093
页数：5
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