Development of Portable Quartz Crystal Microbalance for Biosensor Applications

被引：0
|
作者：
Liang, Jinxing
Zhang, Jing [1 ]
Wang, Peng [1 ]
Liu, Changchuan [1 ]
Qiu, Shi [1 ]
Ueda, Toshitsugu [2 ]
机构：
[1] Southeast Univ, Sch Instrument Sci & Engn, Key Lab Microinertial Instrument & Adv Nav Techno, Minist Educ, 2 Sipailou, Nanjing 210096, Jiangsu, Peoples R China
[2] Waseda Univ, Grad Sch Informat Prod & Syst, Kitakyushu, Fukuoka 8080135, Japan
来源：
SENSORS AND MATERIALS | 2016年 / 28卷 / 03期
关键词：
quartz crystal microbalance; flow injection analysis; high frequency; biosensor; QCM; IMMUNOSENSOR; SURFACE; SPR; SENSORS; ARRAY; WATER; CELL;
D O I：
暂无
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
In this work, we report a novel flow-injection-type portable quartz crystal microbalance (QCM) sensor utilizing a high-frequency (higher than 40 MHz) miniaturized QCM chip. The resonator chip is assembled in a novel three-layer flow cell, in which the top and bottom layers are used to fix the spring-pin leading electrodes and the middle layer is used to house the resonator chip. A two-stage operational transconductance-amplifier-(OPA660)-based oscillator circuit is developed to drive the QCM and measure the frequency shift. A low human IgG concentration of 1 ppm has been measured even using the simple physical adsorption antibody immobilization method, which indicates that the developed portable QCM sensor can be used as a biosensor in liquids.
引用
收藏
页码：201 / 207
页数：7
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