Antidepressant and anxiolytic-like effects of essential oil from Acantholippia deserticola Phil in female rats

被引：0

作者：

Benites, Julio ^{[1
,2
]}

Bustos, Luis ^{[1
]}

Rios, David ^{[1
,2
]}

Bravo, Felipe ^{[1
,2
]}

Lopez, Jose ^{[1
,2
]}

Gajardo, Sandra ^{[1
,2
]}

Rojo, Leonel ^{[1
,2
]}

Buc-Calderon, Pedro ^{[1
,2
,3
]}

机构：

[1] Univ Arturo Prat, Fac Ciencias Salud, Iquique, Chile

[2] Univ Arturo Prat, Inst EtnoFarmacol IDE, Iquique, Chile

[3] Catholic Univ Louvain, LDRI, Res Grp Toxicol & Canc Cell Biol GTOX, B-1200 Brussels, Belgium

来源：

BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS | 2013年 / 12卷 / 04期

关键词：

Acantholippia deserticola; Verbenacea; thujone; anxiolytic and antidepressant effects; HYDROALCOHOLIC EXTRACT; ALPHA-THUJONE; PLUS-MAZE; ABSINTHE; ANXIETY; MODULATION;

D O I：

暂无

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Acantholippia deserticola (Phil. ex F. Phil.) Moldenke is a Verbenaceae that has long been used in traditional medicine in Tarapaca (Chile) as an analgesic, anti-inflammatory and aphrodisiac agent. Since alpha- and beta-thujone were identified as the main constituents (88.4%) of the essential oil from this plant, we investigated its biological properties. The results show that the essential oil from Acantholippia deserticola decreased locomotive and rearing activity compared to control group rats, including those treated with diazepam, but the essential oil had no effects on head movements or grooming. The essential oil also had significant anxiolytic and antidepressant effects. This essential oil, therefore, has sedative, anxiolytic and antidepressant actions on the rat central nervous system.

引用

页码：413 / 419

页数：7

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