Delivery of DNA vaccines by attenuated intracellular bacteria

被引：45

作者：

Dietrich, G ^{[1
]}

Gentschev, I

Hess, J

Ulmer, JB

Kaufmann, SHE

Goebel, W

机构：

[1] Chiron Behring, Preclin Res Vaccines, D-35006 Marburg, Germany

[2] Univ Wurzburg, Dept Microbiol, D-97074 Wurzburg, Germany

[3] Max Planck Inst Infect Biol, D-10117 Berlin, Germany

[4] Chiron Corp, Chiron Technol, Emeryville, CA 94608 USA

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 06期

关键词：

D O I：

10.1016/S0167-5699(98)01431-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Professional antigen-presenting cells (APCs) play a key role in the induction of immune responses evoked by vaccination with plasmid DNA. Use of attenuated intracellular bacteria as delivery vehicles has the potential to efficiently target DNA vaccines to professional APCs.

引用

页码：251 / 253

页数：3

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