Mesoporous hollow hydroxyapatite capped with smart polymer for multi-stimuli remotely controlled drug delivery

被引：28
作者：
Chen, Ruixia [1 ,2 ]
Shi, Jun [1 ,2 ]
Zhu, Beibei [1 ,2 ]
Zhang, Li [1 ,2 ]
Cao, Shaokui [1 ,2 ]
机构：
[1] Zhengzhou Univ, Sch Mat Sci & Engn, Zhengzhou 450001, Peoples R China
[2] Zhengzhou Univ, Henan Key Lab Adv Nylon Mat & Applicat, Zhengzhou 450001, Peoples R China
来源：
MICROPOROUS AND MESOPOROUS MATERIALS | 2020年 / 306卷
关键词：
Hydroxyapatite; Gold nanorods; Poly(N-isopropylacrylamide-co-acrylic acid); Microcapsules; Thermal-/pH-/NIR-responsiveness; HYBRID MICROPARTICLES; N-ISOPROPYLACRYLAMIDE; SILICA NANOPARTICLES; GOLD NANORODS; TEMPERATURE; RELEASE; CORE; MICROCAPSULES; SHELL; OXIDE;
D O I：
10.1016/j.micromeso.2020.110447
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In this paper, a pH-/thermal-/NIR multi-responsive drug delivery platform based on hollow hydroxyapatite (H-HAP), poly(N-isopropylacrylamide- co-acrylic acid) (PNA) and gold nanorods (AuNRs) were prepared via electrostatic self-assembly. Thermal-sensitive PNA and near-infrared (NIR) responsive AuNRs were capped on the surface of mesoporous hollow HAP to obstruct the initial burst release of HAP and endow the vehicles with multi-responsive drug delivery properties. Notable pH-/thermal-/NIR multi-responsive drug release properties were clearly observed for H-HAP/PNA/AuNRs hybrid microcapsules. In addition, relatively high DOX release could be found for H-HAP/PNA/AuNRs hybrid microcapsules at pH 4.5 upon NIR laser irradiation, due to the corrosion of H-HAP in acidic media and the synergistically photothermal effect between AuNRs and PNA. This study provides a feasible method to fabricate intelligently controllable hybrid drug carriers, which shows great potential in controllable drug delivery.
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页数：11
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