Functional peptide-based drug delivery systems

被引:60
作者
Lian, Zheng [1 ]
Ji, Tianjiao [2 ]
机构
[1] Peoples Publ Secur Univ China, Beijing 100038, Peoples R China
[2] Harvard Med Sch, Boston Childrens Hosp, Dept Anesthesiol, Lab Biomat & Drug Delivery, Boston, MA 02115 USA
关键词
CELL-PENETRATING PEPTIDES; CONTROLLED-RELEASE; TARGETED DELIVERY; GENE DELIVERY; POLYMERIC NANOPARTICLES; THERAPEUTIC PEPTIDE; CANCER-THERAPY; BLOOD-VESSELS; PHAGE DISPLAY; LUNG-CANCER;
D O I
10.1039/d0tb00713g
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Peptides are one of the most important functional motifs for constructing smart drug delivery systems (DDSs). Functional peptides can be conjugated with drugs or carriersviacovalent bonds, or assembled into DDSsviasupramolecular forces, which enables the DDSs to acquire desired functions such as targeting and/or environmental responsiveness. In this mini review, we first introduce the different types of functional peptides that are commonly used for constructing DDSs, and we highlight representative strategies for designing smart DDSs by using functional peptides in the past few years. We also state the challenges of peptide-based DDSs and come up with prospects.
引用
收藏
页码:6517 / 6529
页数:13
相关论文
共 142 条
[1]   Self-Assembled Peptide- and Protein-Based Nanomaterials for Antitumor Photodynamic and Photothermal Therapy [J].
Abbas, Manzar ;
Zou, Qianli ;
Li, Shukun ;
Yan, Xuehai .
ADVANCED MATERIALS, 2017, 29 (12)
[2]   Lipid-Peptide Vesicle Nanoscale Hybrids for Triggered Drug Release by Mild Hyperthermia in Vitro and in Vivo [J].
Al-Ahmady, Zahraa S. ;
Al-Jamal, Wafa' T. ;
Bossche, Jeroen V. ;
Bui, Tam T. ;
Drake, Alex F. ;
Mason, A. James ;
Kostarelos, Kostas .
ACS NANO, 2012, 6 (10) :9335-9346
[3]   pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation [J].
An, Ming ;
Wijesinghe, Dayanjali ;
Andreev, Oleg A. ;
Reshetnyak, Yana K. ;
Engelman, Donald M. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (47) :20246-20250
[4]   Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo [J].
Andreev, Oleg A. ;
Dupuy, Allison D. ;
Segala, Michael ;
Sandugu, Srikanth ;
Serra, David A. ;
Chichester, Clinton O. ;
Engelman, Donald M. ;
Reshetnyak, Yana K. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (19) :7893-7898
[5]   Phage-displayed peptides targeting specific tissues and organs [J].
Andrieu, Josu ;
Re, Francesca ;
Russo, Laura ;
Nicotra, Francesco .
JOURNAL OF DRUG TARGETING, 2019, 27 (5-6) :555-565
[6]   Advances in Fmoc solid-phase peptide synthesis [J].
Behrendt, Raymond ;
White, Peter ;
Offer, John .
JOURNAL OF PEPTIDE SCIENCE, 2016, 22 (01) :4-27
[7]   Factors influencing the ability of nuclear localization sequence peptides to enhance nonviral gene delivery [J].
Bremner, KH ;
Seymour, LW ;
Logan, A ;
Read, ML .
BIOCONJUGATE CHEMISTRY, 2004, 15 (01) :152-161
[8]   Doxorubicin: nanotechnological overviews from bench to bedside [J].
Cagel, Maximiliano ;
Grotz, Estefania ;
Bernabeu, Ezequiel ;
Moretton, Marcela A. ;
Chiappetta, Diego A. .
DRUG DISCOVERY TODAY, 2017, 22 (02) :270-281
[9]   Light-Sensitive Polypeptide Hydrogel and Nanorod Composites [J].
Charati, Manoj B. ;
Lee, Ian ;
Hribar, Kolin C. ;
Burdick, Jason A. .
SMALL, 2010, 6 (15) :1608-1611
[10]   Co-Assembly of Heparin and Polypeptide Hybrid Nanoparticles for Biomimetic Delivery and Anti-Thrombus Therapy [J].
Chen, Chengjun ;
Li, Shukun ;
Liu, Kai ;
Ma, Guanghui ;
Yan, Xuehai .
SMALL, 2016, 12 (34) :4719-4725