Detection and Isolation of Dendritic Cells Using Lewis X-Functionalized Magnetic Nanoparticles

被引：8

作者：

Rouhanifard, Sara H. ^{[3
]}

Xie, Ran ^{[1
,2
]}

Zhang, Guoxin ^{[4
]}

Sun, Xiaoming ^{[4
]}

Chen, Xing ^{[1
,2
]}

Wu, Peng ^{[3
]}

机构：

[1] Peking Univ, Beijing Natl Lab Mol Sci, Synthet & Funct Biomol Ctr, Dept Biol Chem,Coll Chem & Mol Engn, Beijing 100871, Peoples R China

[2] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China

[3] Yeshiva Univ, Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA

[4] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China

来源：

BIOMACROMOLECULES | 2012年 / 13卷 / 10期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

DC-SIGN; VACCINES; ANTIGEN;

D O I：

10.1021/bm3007506

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

dendritic cell (DC)-specific intracellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) is a receptor found on DCs that recognizes antigens bearing mannose-rich or fucosylated glycans, including Lewis X (Le(X)). Here, we report the fabrication of magnetic nanoparticles coated with multivalent Le(X) glycans using Cu (I)-catalyzed azide-alkyne cycloaddition. The resulting nanoparticles are selective and biocompatible, serving as a highly efficient tool for DC detection and enrichment.

引用

收藏

页码：3039 / 3045

页数：7

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