Comparison of placental blood microscopy and the ICT HRP2 rapid diagnostic test to detect placental malaria

被引：8

作者：

Aguilar, Ruth ^{[1
,2
,3
]}

Machevo, Sonia ^{[3
]}

Menendez, Clara ^{[1
,2
,3
]}

Bardaji, Azucena ^{[1
,2
,3
]}

Nhabomba, Augusto ^{[3
]}

Alonso, Pedro L. ^{[1
,3
]}

Mayor, Alfredo ^{[1
,2
,3
]}

机构：

[1] Univ Barcelona, Hosp Clin, Barcelona Ctr Int Hlth Res CRESIB, Barcelona, Spain

[2] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[3] CISM, Maputo, Mozambique

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2012年 / 106卷 / 09期

关键词：

Malaria; Placenta; Microscopy; HRP2; RDT; Mozambique; SOUTHERN GHANA; PREGNANCY; BURDEN;

D O I：

10.1016/j.trstmh.2012.05.001

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Monitoring interventions to prevent malaria in pregnancy requires sensitive detection of placental infection. Rapid diagnostic tests (RDTs) are good candidates, but little information is available on their sensitivity on placental blood. We have evaluated the agreement (kappa coefficient) between microscopy and a Plasmodium falciparum histidine-rich protein 2 (HRP2)-based immuno-chromatographic test (ICT) on placental blood from 1151 women at delivery. Prevalences of placental infection by microscopy and RDT were 5.1% and 5.0%, respectively, showing 82.9% agreement (p < 0.0001). Discordances were found at low parasitemias (<500 parasites/mu L) or negative microscopy. The results suggest that the HRP2-RDTs from ICT diagnostics is a good alternative to microscopy for diagnosing placental malaria at delivery. (c) 2012 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

收藏

页码：573 / 575

页数：3

相关论文

共 10 条

[1] Efficacy of the RTS,S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children:: randomised controlled trial [J].

Alonso, PL ;

Sacarlal, J ;

Aponte, JJ ;

Leach, A ;

Macete, E ;

Milman, J ;

Mandomando, I ;

Spiessens, B ;

Guinovart, C ;

Espasa, M ;

Bassat, Q ;

Aide, P ;

Ofori-Anyinam, O ;

Navia, MM ;

Corachan, S ;

Ceuppens, M ;

Dubois, MC ;

Demoitié, MA ;

Dubovsky, F ;

Menéndez, C ;

Tornieporth, N ;

Ballou, WR ;

Thompson, R ;

Cohen, J .

LANCET, 2004, 364 (9443) :1411-1420

[2] A GOODNESS-OF-FIT APPROACH TO INFERENCE PROCEDURES FOR THE KAPPA-STATISTIC - CONFIDENCE-INTERVAL CONSTRUCTION, SIGNIFICANCE-TESTING AND SAMPLE-SIZE ESTIMATION [J].

DONNER, A ;

ELIASZIW, M .

STATISTICS IN MEDICINE, 1992, 11 (11) :1511-1519

[3] Decline of placental malaria in southern Ghana after the implementation of intermittent preventive treatment in pregnancy [J].

Hommerich, Lena ;

von Oertzen, Christa ;

Bedu-Addo, George ;

Holmberg, Ville ;

Acquah, Patrick A. ;

Eggelte, Teunis A. ;

Bienzle, Ulrich ;

Mockenhaupt, Frank P. .

MALARIA JOURNAL, 2007, 6 (1)

[4] Real-time quantitative PCR for determining the burden of Plasmodium falciparum parasites during pregnancy and infancy [J].

Malhotra, I ;

Dent, A ;

Mungai, P ;

Muchiri, E ;

King, CL .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (08) :3630-3635

[5] Diagnosis of placental malaria [J].

Mockenhaupt, FP ;

Ulmen, U ;

von Gaertner, C ;

Bedu-Addo, G ;

Bienzle, U .

JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (01) :306-308

[6] Detection and clinical manifestation of placental malaria in southern Ghana [J].

Mockenhaupt, Frank P. ;

Bedu-Addo, George ;

von Gaertner, Christiane ;

Boye, Renate ;

Fricke, Katrin ;

Hannibal, Iris ;

Karakaya, Filiz ;

Schaller, Marieke ;

Ulmen, Ulrike ;

Acquah, Patrick A. ;

Dietz, Ekkehart ;

Eggelte, Teunis A. ;

Bienzle, Ulrich .

MALARIA JOURNAL, 2006, 5 (1)

[7]

Singer LM, 2004, AM J TROP MED HYG, V70, P481

[8] Evaluation of a rapid diagnostic test for assessing the burden of malaria at delivery in India [J].

Singh, N ;

Saxena, A ;

Awadhia, SB ;

Shrivastava, R ;

Singh, MP .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2005, 73 (05) :855-858

[9] Coverage of intermittent prevention treatment with sulphadoxine-pyrimethamine among pregnant women and congenital malaria in Cote d'Ivoire [J].

Vanga-Bosson, Henriette A. ;

Coffie, Patrick A. ;

Kanhon, Serge ;

Sloan, Caroline ;

Kouakou, Firmin ;

Eholie, Serge P. ;

Kone, Moussa ;

Dabis, Francois ;

Menan, Herve ;

Ekouevi, Didier K. .

MALARIA JOURNAL, 2011, 10

[10] A review of malaria diagnostic tools: Microscopy and rapid diagnostic test (RDT) [J].

Wongsrichanalai, Chansuda ;

Barcus, Mazie J. ;

Muth, Sinuon ;

Sutamihardja, Awalludin ;

Wernsdorfer, Walther H. .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2007, 77 (06) :119-127