Regulatory cells in allergen-specific immunotherapy

被引：5

作者：

Soyka, Michael B. ^{[1
,2
]}

Holzmann, David ^{[2
]}

Akdis, Cezmi A. ^{[1
]}

机构：

[1] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland

[2] Univ Zurich Hosp, Dept Otorhinolaryngol Head & Neck Surg, CH-8091 Zurich, Switzerland

来源：

IMMUNOTHERAPY | 2012年 / 4卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

allergen; immunotherapy; regulatory; SIT; SLIT; specific; T cell; T-CELLS; DENDRITIC CELLS; TGF-BETA; SUBLINGUAL IMMUNOTHERAPY; IMMUNOLOGICAL MECHANISMS; VENOM IMMUNOTHERAPY; IMMUNE-RESPONSES; ORAL-MUCOSA; SAFETY; INDUCTION;

D O I：

10.2217/IMT.12.10

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Allergen-specific immunotherapy (SIT) is currently the best available curative treatment in allergies and has been used for the treatment of patients for the past 100 years. The formation of a Th2 cell predominant inflammation in addition to production of allergen-specific IgE, the attraction of proinflammatory cells and the degranulation of effector cells, such as mast cells, are essential mechanisms in allergy development. Tregs aim to diminish these effects by IL-10- and TGF-beta-mediated anti-inflammatory reactions and therefore are one of the main targets in SIT. The induction of allergen tolerance is the key to successful SIT. With a special focus on Tregs, this review aims to clarify what is currently known about allergy development and the mode of action in allergen-SIT, which helps to develop further therapeutic strategies in the fight against allergic diseases.

引用

页码：389 / 396

页数：8

共 79 条

[1] Epitope-specific T cell tolerance to phospholipase A(2) in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro [J].

Akdis, CA ;

Akdis, M ;

Blesken, T ;

Wymann, D ;

Alkan, SS ;

Muller, U ;

Blaser, K .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (07) :1676-1683

[2] Allergy and hypersensitivity mechanisms of allergic disease - Editorial overview [J].

Akdis, Cezmi A. .

CURRENT OPINION IN IMMUNOLOGY, 2006, 18 (06) :718-726

[3] Mechanisms of allergen-specific immunotherapy [J].

Akdis, Cezmi A. ;

Akdis, Muebeccel .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 127 (01) :18-27

[4] Mechanisms and treatment of allergic disease in the big picture of regulatory T cells [J].

Akdis, Cezmi A. ;

Akdis, Muebeccel .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (04) :735-746

[5] Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells [J].

Akdis, M ;

Verhagen, J ;

Taylor, A ;

Karamloo, F ;

Karagiannidis, C ;

Crameri, R ;

Thunberg, S ;

Deniz, G ;

Valenta, R ;

Fiebig, H ;

Kegel, C ;

Disch, R ;

Schmidt-Weber, CB ;

Blaser, K ;

Akdis, CA .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (11) :1567-1575

[6]

Akdis M, 2011, J ALLERGY CLIN IMMUN, V127, P701

[7] Therapeutic manipulation of immune tolerance in allergic disease [J].

Akdis, Muebeccel ;

Akdis, Cezmi A. .

NATURE REVIEWS DRUG DISCOVERY, 2009, 8 (08) :645-660

[8] Increased activation-induced cell death of high IFN-γ-producing TH1 cells as a mechanism of TH2 predominance in atopic diseases [J].

Akkoc, Tunc ;

de Koning, Pieter J. A. ;

Ruckert, Beate ;

Barlan, Isil ;

Akdis, Mubeccel ;

Akdis, Cezmi A. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2008, 121 (03) :652-658

[9] Characterization of dendritic cells from human oral mucosa:: A new Langerhans' cell type with high constitutive Fcε_RI expression [J].

Allam, JP ;

Novak, N ;

Fuchs, C ;

Asen, S ;

Bergé, S ;

Appel, T ;

Geiger, E ;

Kochan, JP ;

Bieber, T .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 112 (01) :141-148

[10] Response to sublingual immunotherapy with grass pollen extract: Monotherapy versus combination in a multiallergen extract [J].

Amar, Sheila M. ;

Harbeck, Ronald J. ;

Sills, Michael ;

Silveira, Lori J. ;

O'Brien, Holly ;

Nelson, Harold S. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 124 (01) :150-156

← 1 2 3 4 5 6 7 8 →