Cyclic sulfamidates as lactam precursors. An efficient asymmetric synthesis of (-)-aphanorphine

被引：55

作者：

Bower, JF

Szeto, P

Gallagher, T

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] GlaxoSmithKline Inc, Chem Dev, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 46期

关键词：

D O I：

10.1039/b510761j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A short and efficient enantioselective synthesis of (-)-aphanorphine is described based on the use of a cyclic sulfamidate to provide a suitably functionalised lactam that allows for construction of the tricyclic 3-benzazepine scaffold.

引用

页码：5793 / 5795

页数：3

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