Recent advances in optical biosensors for the detection of cancer biomarker α-fetoprotein (AFP)

被引：68
作者：
Kal-Koshvandi, Afsaneh Taheri [1 ]
机构：
[1] Alzahra Univ, Dept Chem, Tehran, Iran
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2020年 / 128卷
关键词：
alpha-fetoprotein; Optical biosensors; Cancer; Biomarker; Detection; ENHANCED RAMAN-SCATTERING; SIGNAL AMPLIFICATION STRATEGY; RESONANCE ENERGY-TRANSFER; PROSTATE-SPECIFIC ANTIGEN; FLUORESCENT GOLD NANOCLUSTERS; LABEL-FREE; PHOTOELECTROCHEMICAL BIOSENSOR; QUANTUM DOTS; ELECTROCHEMILUMINESCENT IMMUNOSENSOR; ELECTROGENERATED CHEMILUMINESCENCE;
D O I：
10.1016/j.trac.2020.115920
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
alpha-fetoprotein (AFP) as a target marker refers to albuminoid proteins, which is a tumor-related fetal protein, increasing the AFP concentration leads to various diseases, including liver cancer. Therefore, it is essential to develop fast, ultrasensitive and selective methods for early detection at trace levels. Several biosensing platforms have been developed concerning this purpose. The novel optical biosensors is developing as one of the most effective methods. The visibility of the target marker without employing any costly tools makes optical detection better than other methods. So, this review throws light on the role of this novel biosensors to the early detection of AFP, which is important in cancer diagnoses. (C) 2020 Elsevier B.V. All rights reserved.
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页数：16
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