Flash nanoprecipitation with Gd(III)-based metallosurfactants to fabricate polylactic acid nanoparticles as highly efficient contrast agents for magnetic resonance imaging

被引:9
作者
Xu, Kehan [1 ]
Wang, Mingwei [2 ]
Tang, Weijun [3 ]
Ding, Yun [1 ]
Hu, Aiguo [1 ]
机构
[1] East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Shanghai 200237, Peoples R China
[2] East China Univ Sci & Technol, Sch Chem Engn, State Key Lab Chem Engn, Shanghai 200237, Peoples R China
[3] Fudan Univ, Huashan Hosp, Dept Radiol, Shanghai 200040, Peoples R China
基金
中国国家自然科学基金;
关键词
Magnetic Resonance Imaging; Contrast Agents; Flash Nanoprecipitation; Self-assembly; Nanoparticles; DRUG-DELIVERY; RELAXIVITY; COMPLEX; ASSEMBLIES; STABILITY; COPOLYMER; DESIGN; TUMOR; SIZE;
D O I
10.1002/asia.202000624
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Polylactic acid (PLA) nanoparticles coated with Gd(III)-based metallosurfactants (MS) are prepared using a simple and rapid one-step method, flash nanoprecipitation (FNP), for magnetic resonance imaging (MRI) applications. By co-assembling the Gd(III)-based MS and an amphiphilic polymer, methoxy poly(ethylene glycol)-b-poly(epsilon-caprolactone) (mPEG-b-PCL), PLA cores were rapidly encapsulated to form biocompatible T(1)contrast agents with tunable particle size and narrow size distribution. The hydrophobic property of Gd(III)-based MS were finely tuned to achieve their high loading efficiency. The size of the nanoparticles was easily controlled by tuning the stream velocity, Reynolds number and the amount of the amphiphilic block copolymer during the FNP process. Under the optimized condition, the relaxivity of the nanoparticles was achieved up to 35.39 mM(-1) s(-1)(at 1.5 T), which is over 8 times of clinically used MRI contrast agents, demonstrating the potential application for MR imaging.
引用
收藏
页码:2475 / 2479
页数:5
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