Three-Dimensional Passive Micromixer Fabricated by Two-Photon Polymerization for Microfluidic Mixing

被引:2
作者
Liu, Yi-Jui [2 ,3 ]
Chen, Po-Yu [2 ]
Yang, Jiun-Yi [2 ]
Tsou, Chingfu [2 ]
Lee, Yi-Hsiung [4 ]
Baldeck, Patrice [1 ,5 ]
Lin, Chih-Lang [1 ]
机构
[1] Cent Taiwan Univ Sci & Technol, Inst Biomed Engn & Mat Sci, Taichung 406, Taiwan
[2] Feng Chia Univ, Dept Automat Control Engn, Taichung 407, Taiwan
[3] Feng Chia Univ, Masters Program Biomed Informat & Biomed Engn, Taichung 407, Taiwan
[4] Feng Chia Univ, PhD Program Elect & Commun Engn, Taichung 407, Taiwan
[5] Univ Grenoble 1, CNRS, LIPhy UMR 5588, F-38041 Grenoble, France
关键词
microfluidic; laminar flow; micromixer; two-photon polymerization; passive mixing; active mixing; ON-A-CHIP; PHOTOPOLYMERIZATION;
D O I
暂无
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
Flow mixing is an important process for many microfluidic applications. Efficient mixing is difficult in microscale channels owing to laminar flow. Disturbing the flow stream by modifying channel geometries or embedding barriers improves the mixing rate. In this study, a three-dimensional (3-D) passive micromixer with propeller blades fabricated by two-photon polymerization (TPP) technology is embedded in the channel for fluid mixing. The propeller blades are designed to disturb the laminar flow in three dimensions to improve the mixing rate. Screw-shaped and flat blades are compared. The experimental results indicate that the screw-shaped propeller provides additional streamlines in the Z direction, which enhances the mixing efficiency. Finally, this phenomenon was verified through simulation.
引用
收藏
页码:39 / 44
页数:6
相关论文
共 17 条
[11]   A magnetic microstirrer and array for microfluidic mixing [J].
Lu, LH ;
Ryu, KS ;
Liu, C .
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 2002, 11 (05) :462-469
[12]   Three-dimensional microfabrication with two-photon-absorbed photopolymerization [J].
Maruo, S ;
Nakamura, O ;
Kawata, S .
OPTICS LETTERS, 1997, 22 (02) :132-134
[13]  
Moroney R. M., 1991, P IEEE MICR MECH SYS, P227
[14]   PDMS-based micro PCR chip with parylene coating [J].
Shin, YS ;
Cho, K ;
Lim, SH ;
Chung, S ;
Park, SJ ;
Chung, C ;
Han, DC ;
Chang, JK .
JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 2003, 13 (05) :768-774
[15]   A Review on Mixing in Microfluidics [J].
Suh, Yong Kweon ;
Kang, Sangmo .
MICROMACHINES, 2010, 1 (03) :82-111
[16]   Three-dimensional photonic crystal structures achieved with two-photon-absorption photopolymerization of resin [J].
Sun, HB ;
Matsuo, S ;
Misawa, H .
APPLIED PHYSICS LETTERS, 1999, 74 (06) :786-788
[17]   Fabrication of phospholipid bilayer-coated microchannels for on-chip immunoassays [J].
Yang, TL ;
Jung, SY ;
Mao, HB ;
Cremer, PS .
ANALYTICAL CHEMISTRY, 2001, 73 (02) :165-169