APOBEC3B Upregulation and Genomic Mutation Patterns in Serous Ovarian Carcinoma

被引：132

作者：

Leonard, Brandon ^{[1
,2
]}

Hart, Steven N. ^{[3
]}

Burns, Michael B. ^{[1
,2
]}

Carpenter, Michael A. ^{[1
,2
]}

Temiz, Nuri A. ^{[1
,2
]}

Rathore, Anurag ^{[1
,2
]}

Vogel, Rachel I. ^{[1
,2
]}

Nikas, Jason B. ^{[2
]}

Law, Emily K. ^{[1
,2
]}

Brown, William L. ^{[1
,2
]}

Li, Ying

Zhang, Yuji ^{[3
]}

Maurer, Matthew J. ^{[3
]}

Oberg, Ann L. ^{[3
]}

Cunningham, Julie M. ^{[4
,5
]}

Shridhar, Viji ^{[5
]}

Bell, Debra A. ^{[5
]}

April, Craig ^{[13
]}

Bentley, David ^{[13
]}

Bibikova, Marina ^{[13
]}

Cheetham, R. Keira ^{[13
]}

Fan, Jian-Bing ^{[13
]}

Grocock, Russell ^{[13
]}

Humphray, Sean ^{[13
]}

Kingsbury, Zoya ^{[13
]}

Peden, John ^{[13
]}

Chien, Jeremy ^{[11
]}

Swisher, Elizabeth M. ^{[12
]}

Hartmann, Lynn C. ^{[6
]}

Kalli, Kimberly R. ^{[10
]}

Goode, Ellen L. ^{[7
]}

Sicotte, Hugues ^{[7
]}

Kaufmann, Scott H. ^{[8
,9
]}

Harris, Reuben S. ^{[1
,2
]}

机构：

[1] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Mason Canc Ctr, Minneapolis, MN 55455 USA

[3] Mayo Clin, Ctr Canc, Dept Hlth Sci Res, Div Biomed Stat & Informat, Rochester, MN USA

[4] Mayo Clin, Ctr Canc, Med Genome Facil, Rochester, MN USA

[5] Mayo Clin, Ctr Canc, Dept Lab Med & Pathol, Rochester, MN USA

[6] Mayo Clin, Ctr Canc, Dept Oncol, Div Med Oncol, Rochester, MN USA

[7] Mayo Clin, Ctr Canc, Dept Hlth Sci Res, Div Epidemiol, Rochester, MN USA

[8] Mayo Clin, Ctr Canc, Dept Oncol, Div Oncol Res, Rochester, MN USA

[9] Mayo Clin, Ctr Canc, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA

[10] Mayo Clin, Ctr Canc, Womens Canc Program, Rochester, MN USA

[11] Univ Kansas, Dept Canc Biol, Kansas City, KS USA

[12] Univ Washington, Sch Med, Dept Obstet & Gynecol, Seattle, WA 98195 USA

[13] Illumina Cam bridge Ltd, Cambridge, England

来源：

CANCER RESEARCH | 2013年 / 73卷 / 24期

关键词：

B-CELL LYMPHOMA; SOMATIC MUTATIONS; AID/APOBEC FAMILY; FALLOPIAN-TUBE; FOREIGN DNA; AID; RESTRICTION; DEAMINATION; LOCALIZATION; MUTAGENESIS;

D O I：

10.1158/0008-5472.CAN-13-1753

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ovarian cancer is a clinically and molecularly heterogeneous disease. The driving forces behind this variability are unknown. Here, we report wide variation in the expression of the DNA cytosine deaminase APOBEC3B, with elevated expression in the majority of ovarian cancer cell lines (three SDs above the mean of normal ovarian surface epithelial cells) and high-grade primary ovarian cancers. APOBEC3B is active in the nucleus of several ovarian cancer cell lines and elicits a biochemical preference for deamination of cytosines in 5'-TC dinucleotides. Importantly, examination of whole-genome sequence from 16 ovarian cancers reveals that APOBEC3B expression correlates with total mutation load as well as elevated levels of transversion mutations. In particular, high APOBEC3B expression correlates with C- to-A and C- to-G transversion mutations within 5'-TC dinucleotide motifs in early-stage high-grade serous ovarian cancer genomes, suggesting that APOBEC3B-catalyzed genomic uracil lesions are further processed by downstream DNA "repair" enzymes including error-prone translesion polymerases. These data identify a potential role for APOBEC3B in serous ovarian cancer genomic instability. (C)2013 AACR.

引用

页码：7222 / 7231

页数：10

共 40 条

[1] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[2] Integrated genomic analyses of ovarian carcinoma [J].

Bell, D. ;

Berchuck, A. ;

Birrer, M. ;

Chien, J. ;

Cramer, D. W. ;

Dao, F. ;

Dhir, R. ;

DiSaia, P. ;

Gabra, H. ;

Glenn, P. ;

Godwin, A. K. ;

Gross, J. ;

Hartmann, L. ;

Huang, M. ;

Huntsman, D. G. ;

Iacocca, M. ;

Imielinski, M. ;

Kalloger, S. ;

Karlan, B. Y. ;

Levine, D. A. ;

Mills, G. B. ;

Morrison, C. ;

Mutch, D. ;

Olvera, N. ;

Orsulic, S. ;

Park, K. ;

Petrelli, N. ;

Rabeno, B. ;

Rader, J. S. ;

Sikic, B. I. ;

Smith-McCune, K. ;

Sood, A. K. ;

Bowtell, D. ;

Penny, R. ;

Testa, J. R. ;

Chang, K. ;

Dinh, H. H. ;

Drummond, J. A. ;

Fowler, G. ;

Gunaratne, P. ;

Hawes, A. C. ;

Kovar, C. L. ;

Lewis, L. R. ;

Morgan, M. B. ;

Newsham, I. F. ;

Santibanez, J. ;

Reid, J. G. ;

Trevino, L. R. ;

Wu, Y. -Q. ;

Wang, M. .

NATURE, 2011, 474 (7353) :609-615

[3] APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cells [J].

Bogerd, HP ;

Wiegand, HL ;

Doehle, BP ;

Lueders, KK ;

Cullen, BR .

NUCLEIC ACIDS RESEARCH, 2006, 34 (01) :89-95

[4] Evidence for APOBEC3B mutagenesis in multiple human cancers [J].

Burns, Michael B. ;

Temiz, Nuri A. ;

Harris, Reuben S. .

NATURE GENETICS, 2013, 45 (09) :977-+

[5] APOBEC3B is an enzymatic source of mutation in breast cancer [J].

Burns, Michael B. ;

Lackey, Lela ;

Carpenter, Michael A. ;

Rathore, Anurag ;

Land, Allison M. ;

Leonard, Brandon ;

Refsland, Eric W. ;

Kotandeniya, Delshanee ;

Tretyakova, Natalia ;

Nikas, Jason B. ;

Yee, Douglas ;

Temiz, Nuri I. A. ;

Donohue, Duncan E. ;

McDougle, Rebecca M. ;

Brown, William L. ;

Law, Emily K. ;

Harris, Reuben S. .

NATURE, 2013, 494 (7437) :366-370

[6] Methylcytosine and Normal Cytosine Deamination by the Foreign DNA Restriction Enzyme APOBEC3A [J].

Carpenter, Michael A. ;

Li, Ming ;

Rathore, Anurag ;

Lackey, Lela ;

Law, Emily K. ;

Land, Allison M. ;

Leonard, Brandon ;

Shandilya, Shivender M. D. ;

Bohn, Markus-Frederik ;

Schiffer, Celia A. ;

Brown, William L. ;

Harris, Reuben S. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (41) :34801-34808

[7] The AID/APOBEC family of nucleic acid mutators [J].

Conticello, Silvestro G. .

GENOME BIOLOGY, 2008, 9 (06)

[8] Molecular mechanisms of antibody somatic hypermutation [J].

Di Nola, Javier M. ;

Neuberger, Michael S. .

ANNUAL REVIEW OF BIOCHEMISTRY, 2007, 76 :1-22

[9] Patterns of somatic mutation in human cancer genomes [J].

Greenman, Christopher ;

Stephens, Philip ;

Smith, Raffaella ;

Dalgliesh, Gillian L. ;

Hunter, Christopher ;

Bignell, Graham ;

Davies, Helen ;

Teague, Jon ;

Butler, Adam ;

Edkins, Sarah ;

O'Meara, Sarah ;

Vastrik, Imre ;

Schmidt, Esther E. ;

Avis, Tim ;

Barthorpe, Syd ;

Bhamra, Gurpreet ;

Buck, Gemma ;

Choudhury, Bhudipa ;

Clements, Jody ;

Cole, Jennifer ;

Dicks, Ed ;

Forbes, Simon ;

Gray, Kris ;

Halliday, Kelly ;

Harrison, Rachel ;

Hills, Katy ;

Hinton, Jon ;

Jenkinson, Andy ;

Jones, David ;

Menzies, Andy ;

Mironenko, Tatiana ;

Perry, Janet ;

Raine, Keiran ;

Richardson, Dave ;

Shepherd, Rebecca ;

Small, Alexandra ;

Tofts, Calli ;

Varian, Jennifer ;

Webb, Tony ;

West, Sofie ;

Widaa, Sara ;

Yates, Andy ;

Cahill, Daniel P. ;

Louis, David N. ;

Goldstraw, Peter ;

Nicholson, Andrew G. ;

Brasseur, Francis ;

Looijenga, Leendert ;

Weber, Barbara L. ;

Chiew, Yoke-Eng .

NATURE, 2007, 446 (7132) :153-158

[10] The Restriction Factors of Human Immunodeficiency Virus [J].

Harris, Reuben S. ;

Hultquist, Judd F. ;

Evans, David T. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (49) :40875-40883

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