Thymic Regulatory T Cell Development: Role of Signalling Pathways and Transcription Factors

被引：15

作者：

Engel, Mark ^{[1
]}

Sidwell, Tom ^{[2
]}

Vasanthakumar, Ajithkumar ^{[2
]}

Grigoriadis, George ^{[1
,3
]}

Banerjee, Ashish ^{[1
]}

机构：

[1] Monash Univ, Southern Clin Sch, Monash Med Ctr, Ctr Inflammatory Dis, Clayton, Vic 3168, Australia

[2] Walter & Eliza Hall Inst Med Res, Mol Immunol Div, Melbourne, Vic 3052, Australia

[3] Cent Clin Sch, Dept Clin Haematol, Melbourne, Vic 3000, Australia

来源：

CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2013年

关键词：

NF-KAPPA-B; X-LINKED SYNDROME; FOXP3; EXPRESSION; CUTTING EDGE; C-REL; DIFFERENTIAL REQUIREMENT; CD28; COSTIMULATION; SELF-TOLERANCE; NUCLEAR-FACTOR; CALCINEURIN;

D O I：

10.1155/2013/617595

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T cells (Tregs) are a subset of CD4 T cells that are key mediators of immune tolerance. Most Tregs develop in the thymus. In this review we summarise recent findings on the role of diverse signalling pathways and downstream transcription factors in thymic Treg development.

引用

页数：8

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