Thymic Regulatory T Cell Development: Role of Signalling Pathways and Transcription Factors

被引：15
|
作者：
Engel, Mark [1 ]
Sidwell, Tom [2 ]
Vasanthakumar, Ajithkumar [2 ]
Grigoriadis, George [1 ,3 ]
Banerjee, Ashish [1 ]
机构：
[1] Monash Univ, Southern Clin Sch, Monash Med Ctr, Ctr Inflammatory Dis, Clayton, Vic 3168, Australia
[2] Walter & Eliza Hall Inst Med Res, Mol Immunol Div, Melbourne, Vic 3052, Australia
[3] Cent Clin Sch, Dept Clin Haematol, Melbourne, Vic 3000, Australia
来源：
CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2013年
关键词：
NF-KAPPA-B; X-LINKED SYNDROME; FOXP3; EXPRESSION; CUTTING EDGE; C-REL; DIFFERENTIAL REQUIREMENT; CD28; COSTIMULATION; SELF-TOLERANCE; NUCLEAR-FACTOR; CALCINEURIN;
D O I：
10.1155/2013/617595
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Regulatory T cells (Tregs) are a subset of CD4 T cells that are key mediators of immune tolerance. Most Tregs develop in the thymus. In this review we summarise recent findings on the role of diverse signalling pathways and downstream transcription factors in thymic Treg development.
引用
收藏
页数：8
相关论文
共 50 条
  • [21] Role of hedgehog signalling in T-cell development
    Al-Shammary, A.
    Sahni, H.
    Furmanski, A.
    Crompton, T.
    IMMUNOLOGY, 2013, 140 : 207 - 207
  • [22] Investigating the role of lineage commitment in thymic T cell development
    Peters, G.
    Pang, D. J.
    Aguirre, A. M.
    Pennington, D. J.
    IMMUNOLOGY, 2008, 125 : 130 - 131
  • [23] An essential role for thymic mesenchyme in early T cell development
    Suniara, RK
    Jenkinson, EJ
    Owen, JJT
    JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (06): : 1051 - 1056
  • [24] DOCK8 deficiency diminishes thymic T-regulatory cell development but not thymic deletion
    Randall, Katrina L.
    Law, Hsei Di
    Ziolkowski, Andrew F.
    Wirasinha, Rushika C.
    Goodnow, Christopher C.
    Daley, Stephen R.
    CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2021, 10 (01)
  • [25] Molecular signalling pathways underlying regulatory T cell (Treg)-enhanced oligodendrocyte differentiation
    Dittmer, M.
    Penalva, R.
    Fitzgerald, D. C.
    GLIA, 2019, 67 : E158 - E159
  • [26] Development and Functional Modulation of Regulatory T Cells by Transcription Factors and Epigenetics
    Ito, Minako
    Iizuka-Koga, Mana
    Ando, Makoto
    Yoshimura, Akihiko
    CORNEA, 2018, 37 : S42 - S49
  • [27] Control of Regulatory T Cell Differentiation by the Transcription Factors Thpok and LRF
    Carpenter, Andrea C.
    Wohlfert, Elizabeth
    Chopp, Laura B.
    Vacchio, Melanie S.
    Nie, Jia
    Zhao, Yongmei
    Shetty, Jyoti
    Xiao, Qi
    Deng, Callie
    Tran, Bao
    Cam, Margaret
    Gaida, Matthias M.
    Belkaid, Yasmine
    Bosselut, Remy
    JOURNAL OF IMMUNOLOGY, 2017, 199 (05): : 1716 - 1728
  • [28] TRANSCRIPTION FACTORS IN EARLY T-CELL DEVELOPMENT
    CLEVERS, HC
    OOSTERWEGEL, MA
    GEORGOPOULOS, K
    IMMUNOLOGY TODAY, 1993, 14 (12): : 591 - 596
  • [29] Regulatory T cells: A role for notch signalling
    Lamb, J
    Dallman, MJ
    Hoyne, GF
    CLINICAL AND EXPERIMENTAL ALLERGY, 2001, 31 (01): : 165 - 165
  • [30] Developing a model of thymic regulatory T cell development with single-cell RNA sequencing
    Owen, David L.
    LaRue, Rebecca
    Farrar, Michael A.
    JOURNAL OF IMMUNOLOGY, 2021, 206
12345