Molecular Profiling Reveals Prognostically Significant Subtypes of Canine Lymphoma

被引：80

作者：

Frantz, A. M. ^{[1
,2
]}

Sarver, A. L. ^{[3
]}

Ito, D. ^{[1
,3
]}

Phang, T. L. ^{[4
,5
]}

Karimpour-Fard, A. ^{[5
,6
]}

Scott, M. C. ^{[1
]}

Valli, V. E. O. ^{[7
]}

Lindblad-Toh, K. ^{[8
,9
]}

Burgess, K. E. ^{[10
]}

Husbands, B. D. ^{[1
]}

Henson, M. S. ^{[1
,3
]}

Borgatti, A. ^{[1
,3
]}

Kisseberth, W. C. ^{[11
,12
,13
]}

Hunter, L. E. ^{[5
,6
]}

Breen, M. ^{[14
,15
,16
]}

O'Brien, T. D. ^{[3
,17
,18
]}

Modiano, J. F. ^{[1
,3
,18
,19
]}

机构：

[1] Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN 55108 USA

[2] Univ Minnesota, Coll Vet Med, Comparat Mol Biosci & DVM PhD Combined Grad, St Paul, MN 55108 USA

[3] Univ Minnesota, Mason Canc Ctr, Minneapolis, MN 55455 USA

[4] Univ Colorado, Sch Med, Dept Med, Denver, CO USA

[5] Univ Colorado, Ctr Canc, Aurora, CO USA

[6] Univ Colorado, Sch Med, Dept Pharmacol, Denver, CO 80262 USA

[7] VDx Vet Diagnost, Davis, CA USA

[8] Broad Inst, Cambridge, MA USA

[9] Uppsala Univ, Dept Med Biochem & Microbiol, Sci Life Lab, Uppsala, Sweden

[10] Tufts Cummings Sch Vet Med, Dept Clin Sci, North Grafton, MA USA

[11] Ohio State Univ, Coll Vet Med, Dept Vet Clin Sci, Columbus, OH 43210 USA

[12] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

[13] Ohio State Univ, Solove Res Inst, Columbus, OH 43210 USA

[14] N Carolina State Univ, Coll Vet Med, Dept Mol Biomed Sci, Raleigh, NC USA

[15] N Carolina State Univ, Ctr Comparat Med & Translat Res, Raleigh, NC 27695 USA

[16] UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA

[17] Univ Minnesota, Coll Vet Med, Dept Vet Populat Med, St Paul, MN 55108 USA

[18] Univ Minnesota, Stem Cell Inst, Minneapolis, MN 55455 USA

[19] Univ Minnesota, Ctr Immunol, Minneapolis, MN 55455 USA

来源：

VETERINARY PATHOLOGY | 2013年 / 50卷 / 04期

基金：

美国国家卫生研究院;

关键词：

canine; lymphoma subclassification; gene expression profiling; prognostication; B-CELL LYMPHOMA; CHEMOTHERAPY PROTOCOL; EXPRESSION; MALIGNANCIES; DOGS; HEMANGIOSARCOMA; CLASSIFICATION; INACTIVATION; ORGANIZATION; THERAPY;

D O I：

10.1177/0300985812465325

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We performed genomewide gene expression analysis of 35 samples representing 6 common histologic subtypes of canine lymphoma and bioinformatics analyses to define their molecular characteristics. Three major groups were defined on the basis of gene expression profiles: (1) low-grade T-cell lymphoma, composed entirely by T-zone lymphoma; (2) high-grade T-cell lymphoma, consisting of lymphoblastic T-cell lymphoma and peripheral T-cell lymphoma not otherwise specified; and (3) B-cell lymphoma, consisting of marginal B-cell lymphoma, diffuse large B-cell lymphoma, and Burkitt lymphoma. Interspecies comparative analyses of gene expression profiles also showed that marginal B-cell lymphoma and diffuse large B-cell lymphoma in dogs and humans might represent a continuum of disease with similar drivers. The classification of these diverse tumors into 3 subgroups was prognostically significant, as the groups were directly correlated with event-free survival. Finally, we developed a benchtop diagnostic test based on expression of 4 genes that can robustly classify canine lymphomas into one of these 3 subgroups, enabling a direct clinical application for our results.

引用

页码：693 / 703

页数：11

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