Ligament Tissue Engineering and Its Potential Role in Anterior Cruciate Ligament Reconstruction

被引：22
作者：
Yates, E. W. [1 ]
Rupani, A. [2 ]
Foley, G. T. [1 ]
Khan, W. S. [3 ,4 ]
Cartmell, S. [2 ]
Anand, S. J. [1 ]
机构：
[1] Stepping Hill Hosp, Stockport NHS Fdn Trust, Dept Trauma & Orthopaed, Stockport SK2 7JE, Lancs, England
[2] Univ Manchester, Ctr Mat Sci, Manchester M13 9PT, Lancs, England
[3] Royal Natl Orthopaed Hosp, Stanmore HA7 4LP, Middx, England
[4] Univ Coll London, Inst Orthopaed & Musculoskeletal Sci, Stanmore HA7 4LP, Middx, England
来源：
STEM CELLS INTERNATIONAL | 2012年 / 2012卷
关键词：
MESENCHYMAL STEM-CELLS; BONE-MARROW; SILK SCAFFOLD; STROMAL CELLS; IN-VIVO; TENDON; FIBROBLASTS; DIFFERENTIATION;
D O I：
10.1155/2012/438125
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Tissue engineering is an emerging discipline that combines the principle of science and engineering. It offers an unlimited source of natural tissue substitutes and by using appropriate cells, biomimetic scaffolds, and advanced bioreactors, it is possible that tissue engineering could be implemented in the repair and regeneration of tissue such as bone, cartilage, tendon, and ligament. Whilst repair and regeneration of ligament tissue has been demonstrated in animal studies, further research is needed to improve the biomechanical properties of the engineered ligament if it is to play an important part in the future of human ligament reconstruction surgery. We evaluate the current literature on ligament tissue engineering and its role in anterior cruciate ligament reconstruction.
引用
收藏
页数：6
相关论文
共 47 条
  • [1] Silk matrix for tissue engineered anterior cruciate ligaments
    Altman, GH
    Horan, RL
    Lu, HH
    Moreau, J
    Martin, I
    Richmond, JC
    Kaplan, DL
    [J]. BIOMATERIALS, 2002, 23 (20) : 4131 - 4141
  • [2] Cell differentiation by mechanical stress
    Altman, GH
    Horan, RL
    Martin, I
    Farhadi, J
    Stark, PRH
    Volloch, V
    Richmond, JC
    Vunjak-Novakovic, G
    Kaplan, DL
    [J]. FASEB JOURNAL, 2001, 15 (14) : 270 - +
  • [3] The Therapeutic Applications of Multipotential Mesenchymal/Stromal Stem Cells in Skeletal Tissue Repair
    Arthur, Agnieszka
    Zannettino, Andrew
    Gronthos, Stan
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2009, 218 (02) : 237 - 245
  • [4] Direct cell contact influences bone marrow mesenchymal stem cell fate
    Ball, SG
    Shuttleworth, AC
    Kielty, CM
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2004, 36 (04) : 714 - 727
  • [5] Viability of fibroblast-seeded ligament analogs after autogenous implantation
    Bellincampi, LD
    Closkey, RF
    Prasad, R
    Zawadsky, JP
    Dunn, MG
    [J]. JOURNAL OF ORTHOPAEDIC RESEARCH, 1998, 16 (04) : 414 - 420
  • [6] In vitro comparison of human fibroblasts from intact and ruptured ACL for use in tissue engineering
    Brune, T.
    Borel, A.
    Gilbert, T. W.
    Franceschi, J. P.
    Badylak, S. F.
    Sommer, P.
    [J]. EUROPEAN CELLS & MATERIALS, 2007, 14 : 78 - 90
  • [7] Ligament regeneration using a knitted silk scaffold combined with collagen matrix
    Chen, Xiao
    Qi, Yi-Ying
    Wang, Lin-Lin
    Yin, Zi
    Yin, Guo-Li
    Zou, Xiao-Hui
    Ouyang, Hong-Wei
    [J]. BIOMATERIALS, 2008, 29 (27) : 3683 - 3692
  • [8] Cheng MT, 2010, TISSUE ENG PT A, V16, P2237, DOI 10.1089/ten.TEA.2009.0664
  • [9] Evaluation of the anterior cruciate ligament, medial collateral ligament, achilles tendon and patellar tendon as cell sources for tissue-engineered ligament
    Cooper, JA
    Bailey, LO
    Carter, JN
    Castiglioni, CE
    Kofron, MD
    Ko, FK
    Laurencin, CT
    [J]. BIOMATERIALS, 2006, 27 (13) : 2747 - 2754
  • [10] Techniques for biological characterization of tissue-engineered tendon and ligament
    Doroski, Derek M.
    Brink, Kelly S.
    Temenoff, Johnna S.
    [J]. BIOMATERIALS, 2007, 28 (02) : 187 - 202
12345