Structure and function of dynactin

被引：51
作者：
Schroer, TA
机构：
[1] Department of Biology, Johns Hopkins University, Baltimore
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1996年 / 7卷 / 03期
基金：
美国国家卫生研究院;
关键词：
cytoplasmic dynein; dynactin; microtubules; motility;
D O I：
10.1006/scdb.1996.0041
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Dynactin is a 1.2 mDa protein complex initially isolated as an activator of cytoplasmic dynein-driven vesicle movement in vitro. Genetic studies have verified that dynactin participates in dynein-based transport events as varied as nuclear localization ana axonal transport. Recent work has focused on identification of the IO different polypeptide subunits of dynactin and elucidation of the way in which they are organized within the dynactin molecule. A picture is beginning to emerge as to how this complicated structure interacts with dynein and cytoplasmic organelles to form an assembly capable of motility.
引用
收藏
页码：321 / 328
页数：8
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