Bone-like Resorbable Silk-based Scaffolds for Load-bearing Osteoregenerative Applications

被引：72

作者：

Collins, Andrew M. ^{[1
]}

Skaer, Nick J. V. ^{[2
]}

Cheysens, Tom ^{[2
]}

Knight, David ^{[2
]}

Bertram, Caroline ^{[3
]}

Roach, Helmtrud I. ^{[3
]}

Oreffo, Richard O. C. ^{[3
]}

Von-Aulock, Sonja ^{[4
]}

Baris, Teodoro ^{[4
]}

Skinner, John ^{[5
]}

Mann, Stephen ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Ctr Organized Matter Chem, Bristol BS8 1TS, Avon, England

[2] Oxford BioMat Ltd, Enterprise Ctr, Newbury RG19 6HR, Berks, England

[3] Univ Southampton, Southampton Gen Hosp, Inst Dev Sci, Bone & Joint Res Grp, Southampton SO16 6YD, Hants, England

[4] Univ Konstanz, D-78457 Constance, Germany

[5] Univ Bristol, Fac Engn, Bristol BS8 1TR, Avon, England

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 01期

关键词：

MESENCHYMAL STEM-CELLS; IN-VITRO; BIOMATERIALS; DELIVERY; APATITE; SPIDER;

D O I：

10.1002/adma.200802239

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydroxyapatite/silk biocompatible composites with unprecedented mechanical strength and toughness areproduced in a new process with theintegrated mineralization of macroporous silk fibroin scaffolds. Thebiomimetic bone-like composites areabsorbable and load-bearing with compressive strength, modulus, andtoughness comparable to the mechanical tolerances of cancellous bone.

引用

页码：75 / 78

页数：4

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